Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors

Links between pain and joint degradation are poorly understood. We investigated the role of activation of Toll-like receptors (TLR) by cartilage metabolites in initiating and maintaining the inflammatory loop in OA causing joint destruction.

Source: Osteoarthritis and Cartilage - November 13, 2019 Category: Rheumatology Authors: Neha Sharma, Patryk Drobinski, Ashref Kayed, Zhizhong Chen, Cecilie F. Kjelgaard-Petersen, Thorbj ørn Gantzel, Morten A. Karsdal, Martin Michaelis, Christoph Ladel, Anne-Christine Bay-Jensen, Sven Lindemann, Christian S. Thudium Source Type: research