A Retrospective Case Series Of High-Intensity Focused Ultrasound (HIFU) In Combination With Gemcitabine And Oxaliplatin (Gemox) On Treating Elderly Middle And Advanced Pancreatic Cancer
Conclusion: HIFU can significantly alleviate cancer-related pain and prolong the survival time of patients with pancreatic cancer.
Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocell...
Conclusions: It was feasible and safe to use HIFU for ablation of the pancreas in swine.
emos JP Abstract Chemotherapy is an important part of multimodality pancreatic cancer treatment. After curative resection, adjuvant chemotherapy can significantly improve disease free survival and overall survival. The current standard of care is six months adjuvant chemotherapy with modified folinic acid, 5-fluorouracil, irinotecan and oxaliplatin (mFOLFIRINOX) in patients fit enough for this protocol, otherwise six months of gemcitabine and capecitabine based on the European Study Group for Pancreatic Cancer (ESPAC)-4 study. In patients with metastatic disease, combination chemotherapy according to the FOLFIRINO...
CONCLUSIONS: Important technological advances are presented in ex vivo and preclinical studies, as the real-time thermometry, nanotechnology and hybrid techniques to enhance the thermal outcome. Conversely, a lack of standardization in the clinical employment of the procedures emerged, leading to contrasting results on the safety and feasibility of some analyzed techniques. Uniform conclusions on the safety and feasibility of these techniques for pancreatic cancer will require further structured investigation. PMID: 30428728 [PubMed - as supplied by publisher]
High-intensity focused ultrasound (HIFU) is a novel minimally invasive modality for ablation of various solid tumors including pancreatic cancer. Currently, the thermal effect of HIFU has been mainly used for tumor treatment. However, over coagulation may suppress effective delivery of anti-tumor drug. Recent studies also found that the mechanical effect of HIFU may help to enhance drug delivery although much higher acoustic intensity is necessary. For current HIFU therapy, large equipment is needed to obtain sufficient acoustic intensity and therefore it is often difficult to achieve an adequate acoustic window by extracorporeal transducer.
CONCLUSION: In patients with advanced pancreatic cancer and otherwise limited treatment options, HIFU resulted in significant early and long-lasting pain relief and tumor size reduction over time independent of metastatic status. Clinical data suggest an additional potential survival benefit. PMID: 29665583 [PubMed - as supplied by publisher]
Abstract Pancreatic cancer is a poor prognostic tumor and about 20% of patients are eligible for surgical resection at the time of diagnosis. Recently, minimally invasive procedures have provided promising results as a therapeutic option for locally advanced unresectable pancreatic cancer. In particular, high-intensity focused ultrasound is an emerging noninvasive thermally ablative procedure that may have a dominant role in the future. Although the clinical applications of minimally invasive therapies to pancreatic cancers are still in their infancy, the results at present are promising. PMID: 29191269 [PubMed - in process]