Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase

Conditions:   Staphylococcus Aureus Bacteremia;   Staphylococcus Aureus Endocarditis Interventions:   Drug: Exebacase;   Drug: Placebo Sponsor:   ContraFect Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conclusions: The fact that patient disposition varied across different payors suggests that hospitals are missing opportunities to engage the most vulnerable patients with IE. Given the long-term care required by this condition, hospitals are well-positioned to participate in interventions to initiate substance abuse treatment and help patients navigate outpatient substance abuse treatment options.
Source: Medical Care - Category: Health Management Tags: Brief Report Source Type: research
AbstractA 68-year-old man with cerebral infarction and right hemiplegia was diagnosed with active infective endocarditis, and multiple large vegetations and more than moderate valve regurgitation by three different valves were detected using transthoracic echocardiography. An urgent surgical intervention was selected, and aortic and mitral valve replacements using bioprostheses were initially performed due to large vegetation on both these valves with valve cusp destruction. Residual severe regurgitation persisted despite tricuspid valve plasty; therefore, tricuspid valve replacement using a tissue valve was performed, and...
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Bacteremia risk in preventive and restorative dentistry – prevalence of bacteremia and systemic antibiotics: a review focusing on preventive and restorative dentistry Swiss Dent J. 2019 Dec 09;129(12):1047-1052 Authors: Schmidlin PR, Attin T, Wegehaupt FJ Abstract This review assessed defined specific areas of diagnostic, prophylactic and therapeutic procedures in the field of preventive and restorative dentistry and determined the prevalence and risk of bacteremia, given the assumption that any direct or indirect manipulation of perfused dental and periodontal tissues may lead to bacterial acces...
Source: Schweizer Monatsschrift fur Zahnmedizin - Category: Dentistry Tags: Swiss Dent J Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case Report Source Type: research
We present a contemporary analysis of risk of fatal stroke among more than 7.5 million cancer patients and report that stroke risk varies as a function of disease site, age, gender, marital status, and time after diagnosis. The risk of stroke among cancer patients is two times that of the general population and rises with longer follow-up time. The relative risk of fatal stroke, versus the general population, is highest in those with cancers of the brain and gastrointestinal tract. The plurality of strokes occurs in patients older than 40 years of age with cancers of the prostate, breast, and colorectum. Patients of any ag...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
We examined patients with chronic kidney disease and severe aortic stenosis undergoing SAVR or TAVR procedure between 2007-2017; excluding age90, dialysis, endocarditis, non-aortic valve stenosis, or patients died within 48-hours post-procedure.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Journal of Cardiac Surgery, EarlyView.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: IMAGES IN CARDIAC SURGERY Source Type: research
Publication date: Available online 7 December 2019Source: Microbial PathogenesisAuthor(s): Philippe Bercier, Marcelo Gottschalk, Daniel GrenierAbstractStreptococcus suis is a bacterial pathogen that mainly colonizes the upper respiratory tract of pigs. It is known to cause severe infections such as septicemia, meningitis, arthritis, and endocarditis in pigs and to be responsible for major economic losses in the swine industry worldwide. To better understand the interactions between S. suis and the porcine respiratory epithelium, we investigated the ability of this pathogen to cause damage to the tracheal epithelial barrier...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
A 59-year-old man with a pacemaker who was admitted for evaluation of fever was found to have a redundant loop of the ventricular lead and a vegetation attached to it. An FDG PET/CT revealed a focus of FDG uptake at the ventricular lead loop. Surgical extraction of the pacemaker device confirmed a Propionibacterium acnes pacemaker endocarditis. We hypothesize that the redundant loop of the ventricular lead induced a chronic mechanical stress both to the tricuspid valve and to the lead itself, facilitating the bacterial colonization of the lead.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
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