7T MRI finds promising MS biomarker
Using 7-tesla MRI scans, researchers have identified a potentially valuable...Read more on AuntMinnie.comRelated Reading: 7T MRI opens door to detailed brain images 7T MRI and 3D printing uncover signs of severe MS 7T MRI shows path to MS progression 7T finds epilepsy abnormalities missed at lower field strengths Can 7-tesla MRI make the transition to clinical prime time?
Conclusions: Our review has revealed that human taeniasis and bovine cysticercosis is a considerable burden in Madagascar. A national control program has been developed aiming to decrease the seroprevalence rate from 16 to 10% in 2015. The aim of the country is now to implement a CC control and elimination program. Meanwhile, some massive cysticercosis screenings have been conducted in the capital Antananarivo to drive people's attention on this widespread infection.
Conclusion: TLE patients with interictal schizophrenia-like psychosis showed more widespread and severe white matter impairment, involving the ATR, IFOF and ILF, as well as disrupted network connectivity, particularly in the left limbic and prefrontal cortex, than patients without psychosis.
CONCLUSIONS: The spontaneous neural activity changes in DRE patients caused by VNS were in an ongoing process. Increased ALFF/ReHo in frontal cortex, cingulate gyri, precentral/postcentral gyri, parahippocampal gyri, precuneus, parietal cortex, and cerebellum may implicate in VNS-induced improvement in seizure frequency. PMID: 32965801 [PubMed - as supplied by publisher]
AbstractPurposeThe main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein variesin vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model.ProceduresTwenty Sprague Dawley male rats were administered with multiple systemic doses of saline (control group,n = 5) or kainic acid (5 mg/kg/injection, epileptic group,n = 15). Both groups were scanned at the four phases of TLE (early, latent, transition, and chronic phase) with the [18F]UCB-H PET radiotracer and T2-structural magnetic ...
AbstractPresent project is concerned with the possibility to modulate the neural regulation of food intake by non-invasive stimulation of the vagus nerve. This nerve carries viscero-afferent information from the gut and other internal organs and therefore serves an important role in ingestive behavior. The electrical stimulation of the vagus nerve (VNS) is a qualified procedure in the treatment of drug-resistant epilepsy and depression. Since weight loss is a known common side effect of VNS treatment in patients with implanted devices, VNS is evaluated as a treatment of obesity. To investigate potential VNS-related changes...
CONCLUSIONS: Despite BECTS being considered to have a relative benign course, many studies have documented cognitive and/or behavioral problems in patients diagnosed with this type of epilepsy. In particular, children affected by rolandic epilepsy should receive a complete neuropsychological evaluation at seizure onset considering the high rate of comorbidity with ADHD. A further investigation of the common pathogenic substrate is desirable to better orientate the clinical and therapeutic interventions applied. PMID: 32916583 [PubMed - as supplied by publisher]
CONCLUSIONS: These cases suggest that children with early-onset drug-resistant "generalized" epilepsy are likely to have a genetic basis although the presentation may not be typical of Dravet syndrome. Hence, genetic testing for SCN1A variants is recommended in children with drug-resistant MRI negative focal-onset/generalized-onset bilateral tonic-clonic seizures before subjecting them to exhaustive presurgical workup and to guide appropriate treatment and prognostication. PMID: 32880473 [PubMed - as supplied by publisher]
Abstract OBJECTIVE: We aimed to determine changes in working memory and functional connectivity via functional magnetic resonance imaging (fMRI)-modified Sternberg task after treatment with highly purified cannabidiol (CBD, Epidiolex®; 100 mg/mL) in patients with treatment-resistant epilepsy (TRE). METHODS: Twenty patients with TRE (mean age: 35.8 years; 7 male) performed fMRI Sternberg task before receiving CBD ("PRE") and after reaching stable dosage of CBD (15-25 mg/kg/day; "ON"). Each patient performed 2 runs of the modified Sternberg task during PRE and ON fMRI. Twenty-three...
CONCLUSION: We developed a novel algorithm referred to as the AMCL algorithm with mean PIBs to effectively and automatically detect and segment FLAIR-negative FCD lesions. This work is the first study to apply a CNN-based model to detect and segment FCD lesions in images of FLAIR-negative lesions. PMID: 32809276 [PubMed - as supplied by publisher]
Focal cortical dysplasia (FCD) is a common cause of intractable epilepsy that may be amenable to surgical therapy. FCDs are typically evaluated by using multimodal structural and functional neuroimaging, including magnetic resonance imaging (MRI), 18F-2-fluorodeoxyglucose-positron emission tomography (FDG-PET), single-photon emission computed tomography (SPECT), and magnetoencephalograms. Although MRI is the preferred imaging method to diagnose patients with intractable epilepsy, detection of FCD is not always satisfactory, whereas FDG-PET may enable detection of FCDs even in MRI-negative cases[1,2].