Biomarker Predictors for Immunotherapy Benefit in Breast: Beyond PD-L1

AbstractPurpose of ReviewImmune checkpoint blockade (ICB) has changed the clinical course of multiple cancer types and durable responses have now been observed in breast cancer (BC) patients. Most data suggest that, compared to other subtypes, triple-negative BC (TNBC) patients are more responsive to ICB, and anti-PD-L1 therapy is now approved in PD-L1+ metastatic TNBC, in combination with chemotherapy.Recent FindingsNearly 40% of PD-L1+ TNBC patients did not respond to this combination. Thus, additional biomarkers appear to be necessary to more precisely identify potential responders. A comprehensive analysis of the breast tumor microenvironment (TME) and peripheral blood may identify potential biomarkers for a more accurate selection of patients likely to respond to ICB.SummaryHerein, we summarize key features of the breast TME, and beyond, that may hold predictive power in determining immunotherapy benefit. Incorporation of these features in controlled clinical trials may help further guide personalized care for BC immunotherapy.
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research

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We describe current and emerging combination approaches which may improve patient outcomes in metastatic breast cancer.
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
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Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
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Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
ConclusionsThis case report describes the evolution of TiME and TNBC molecular subtypes/genomics over time with sequential therapies in a TNBC patient with a CR to atezolizumab monotherapy. These data suggest the TiME is pliable and may be manipulated to maximize response to immunotherapy (NCT01375842,https://clinicaltrials.gov/ct2/show/NCT01375842?term=NCT01375842&rank=1).
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
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Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
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Source: Journal of Nanobiotechnology - Category: Nanotechnology Authors: Tags: Research Source Type: research
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Source: Targeted Oncology - Category: Cancer & Oncology Source Type: research
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Source: Surgery - Category: Surgery Authors: Source Type: research
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