Lasting tumor regression of leukemia and lymphoma in mouse models achieved by U-M compound

(Michigan Medicine - University of Michigan) For decades, a transcription factor known as STAT3 has been a major therapeutic target in the treatment of cancer, but it has largely been considered 'undruggable' due to the difficulty of developing compounds to effectively inhibit its activity. Researchers at the University of Michigan Rogel Cancer Center have taken a promising new approach to targeting STAT3 -- one that was able to achieve a long-lasting and nearly complete elimination of tumors in mouse models of leukemia and lymphoma, the authors report in Cancer Cell.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news