P355 association of use of gaba agonist prescription with asthma and allergic rhinoconjunctivitis.

We have previously shown that prescription opioid analgesics for chronic pain are associated with increased coding for allergic rhino-conjunctivitis (ARC) and asthma. As GABA agonists are increasingly used for chronic pain and have immunomodulatory effects, we investigated if their use is associated with ARC and asthma.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research

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The objectives of this article are the following: 1) to examine fibromyalgia and somatic symptom disorder analogy. 2) to discuss stress-evoked neuropathic pain sexual dimorphism, and 3) to propose a neuropathic pathogenesis that may explain how stressed women could develop fibromyalgia. Recent research demonstrates a clear link between fibromyalgia and small fibre neuropathy. Dorsal root ganglia contain the small nerve fibre nuclei. In rodents, physical, chemical, or environmental stressors lead to dorsal root ganglia phenotypic changes and to hyperalgesia. This phenomenon is much more frequent in females. Prolactin, oestr...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: van Campen C(MC, Rowe PC, Verheugt FWA, Visser FC Abstract OBJECTIVES: Muscle pain and fibromyalgia (FM) are common among individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We recently demonstrated that during orthostatic stress testing, adults with ME/CFS reported increased pain. In the current study, we hypothesised that pain pressure thresholds (PPT) would decrease and temporal summation (windup) would increase after head-up tilt testing (HUT), and that the presence of co-morbid FM would be associated with greater change in both measures. METHODS: We studied adult ME/CFS p...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Publication date: Available online 18 September 2020Source: Life SciencesAuthor(s): Nosayba Al-Azzam, Lina Elsalem
Source: Life Sciences - Category: Biology Source Type: research
Discussion: The use of biologic agents did not increase in this interval, but it is higher than in an earlier assessment of the NAMCS. Nearly all systemic immunomodulators are prescribed by dermatologists. The ambulatory uptake of these agents did not alter the use of other treatment modalities within this timeframe. PMID: 32940551 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Mandlik DS, Mandlik SK Abstract Asthma is the most common, long-lasting inflammatory airway disease that affects more than 10% of the world population. It is characterized by bronchial narrowing, airway hyperresponsiveness, vasodilatation, airway edema and stimulation of sensory nerve endings that lead to recurring events of breathlessness, wheezing, chest tightness and coughing. It is the main reason for global morbidity and occurs as a result of the weakening of the immune system in response to exposure to allergens or environmental exposure. In asthma condition, it results in the activation of numerous ...
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research
Conclusions: The use of the standardized MIST tool for EMS to hospital patient handoff was associated with a mixed value on inpatient documentation of prehospital events. After MIST implementation, agreement was higher for mechanism and location of injury and lower for vital signs and treatments. Further research can advance the prehospital to treatment facility handoff process. PMID: 32940577 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research
Authors: Fernández-Carvajal A, González-Muñiz R, Fernández-Ballester G, Ferrer-Montiel A Abstract INTRODUCTION: . Thermo transient receptor potential (thermoTRP) channels are some of the most intensely pursued therapeutic targets of the past decade. They are considered promising targets of numerous diseases including chronic pain and cancer. Modulators of these proteins, in particular TRPV1-4, TRPM8 and TRPA1, have reached clinical development, but none have been approved for clinical practice yet. AREAS COVERED: . The therapeutic potential of targeting thermoTRP channels is discusse...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
The wildfires blazing in the West could hinder developing lungs, worsen asthma and even lead to the condition in those who don ’t have it but are genetically disposed to it.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Children and Childhood Research Asthma Lungs Wildfires Air Pollution Pacific Northwestern States (US) California your-feed-healthcare Source Type: news
Publication date: November 2020Source: Multiple Sclerosis and Related Disorders, Volume 46Author(s): Mia T. Minen, Kathryn B. Schaubhut, Kaitlyn Morio
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Further data suggest that a lower dose of rituximab may offer similar effectiveness with a better safety profile than a higher dose commonly used.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Neurology & Neurosurgery News Source Type: news
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