BCG Revaccination of Healthy Adolescents for the Prevention of Mycobacterium Tuberculosis Sustained Infection

Condition:   Tuberculosis Interventions:   Biological: BCG vaccine SSI;   Biological: Placebo Sponsor:   Bill & Melinda Gates Medical Research Institute Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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CONCLUSION: Although miliary sarcoidosis is rare, physicians should consider sarcoidosis in the differential diagnosis with conditions like tuberculosis, malignancy, and pneumoconiosis when patients present with miliary opacities who do not respond to the traditional treatment. PMID: 31964332 [PubMed - in process]
Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research
CONCLUSION: Tuberculosis can be difficult to diagnose when it only manifests as pericardial effusion especially if the time for exposure is long before the appearance of symptoms and admission. PMID: 31964331 [PubMed - in process]
Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research
[AIM] Maputo -Mozambique's Coordination Mechanism for the Global Fund to Fight AIDS, Tuberculosis and Malaria on Wednesday reached consensus on the need to create strong and resilient health systems that can respond effectively to the challenges of the Sustainable Development Goals (SDGs).
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 22 January 2020Source: Journal de Mycologie MédicaleAuthor(s): Arghadip Samaddar, Anuradha Sharma, Twishi ShrimaliAbstractAcrophialophora fusispora is a soil-borne fungus rarely implicated in human infections. Here, we report a case of pulmonary infection due to A. fusispora in a 59-year-old male who presented with productive cough and gradually progressive dyspnoea for 20 days. He had a past history of pulmonary tuberculosis and was a known case of chronic obstructive pulmonary disease for past five years. He was diagnosed with mixed connective tissue disease and had been receivin...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Publication date: Available online 23 January 2020Source: Inorganica Chimica ActaAuthor(s): Samet Belveren, Samet Poyraz, Mahmut Ülger, Christopher M. Pask, H. Ali DöndaƟ, José M. SansanoAbstractThe synthesis of a mononuclear octahedral [Prolinate2-Na(MeOH)4]−H+ complex is achieved from a [3+2] cycloadduct with excess of NaOMe in methanol. The slow crystallization provides the hexacoordinated complex stabilized by four molecules of solvent. The antibacterial, antifungal and anti-tuberculosis activity of this compound is also evaluated.Graphical abstract
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
[MSF] New York -Doctors Without Borders/M édecins Sans Frontières (MSF) protested in front of the New York Stock Exchange in New York today, demanding the pharmaceutical corporation Johnson&Johnson (J&J) make the tuberculosis (TB) drug bedaquiline available for all people with drug-resistant TB (DR-TB) for no more than a dollar a day. The price of this crucial drug must be lowered to reflect the joint contributions made to its research and development by taxpayers and the global scientific and TB co
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 21 January 2020Source: Preventive Veterinary MedicineAuthor(s): Laetitia Canini, Benoit DurandAbstractFrance was recognized officially bovine tuberculosis (bTB) free by the European Union in 2001, however an increase of bTB detections has been reported since 2004. Even though the recommended method for bTB control is whole herd depopulation, test-and-cull protocols have been authorized in pilot areas since 2008 and in the rest of France since 2014. BTB impact at the state level and on trade has been thoroughly studied, however the consequences of these control measures at a farm level are...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
In this study, specific primers and MGB probes were designed according to the mutation in PstS1 gene, and a sensitive, specific and rapid real-time PCR assay for M. bovis was established. Then the assay was used to detect M. bovis in simulation samples. The minimum detectable concentration is 101 copies for M. bovis DNA. The standard curve showed correlation coefficient between threshold cycle and PstS1 gene fragment copy number was 0.997 and slope is −3.144. The minimum detectable concentration is 101 cells/ml for simulation sample. In addition, M.bovis strain 93006, 14 clinical BCG stains and 7 clinical M.bovi...
Source: Biologicals - Category: Biology Source Type: research
ng Li Pantoea dispersa W18, isolated from contaminated soil, was found to exert antimicrobial activity against Mycobacterium species, including Mycobacterium tuberculosis, an important human pathogen. Here, the anti-mycobacterial compound produced by Pantoea dispersa W18 was purified by a combination of hydrophobic interaction chromatography, cation exchange chromatography, and reverse phase HPLC. Active compounds from Pantoea dispersa W18 were identified as a natural peptide named pantocin wh-1 with a 1927 Da molecular weight. The primary structure of this compound was detected by N-terminal amino acid sequencing....
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ConclusionsTB can have varied presentation and therefore it is essential to keep tubercular infection in differential diagnosis while working up for any infective pathology. Conservative treatment produces good results in vast majority of cases. Surgery is reserved for select indications.
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
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