Two new phenanthrenequinones with cytotoxic activity from the tubers of Pleione bulbocodioides

Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Si-Yuan Shao, Chao Wang, Shao-Wei Han, Shuai LiAbstractTwo new phenanthrenequinones, bulbocodioidins I–J (1 and 2), were isolated from the tubers of Pleione bulbocodioides. They possess a 9(10)H-phenanthren-10(9)-one structure, which is relatively rare from natural sources. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of them were determined by comparison of the experimental and calculated ECD curves. Compound 2 exhibited cytotoxic activity against human breast cancer cell lines (MCF-7) with the IC50 value of 2.1 μM in vitro.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research