Investigating the role of gap junctions in seizure wave propagation.

Investigating the role of gap junctions in seizure wave propagation.
Biol Cybern. 2019 Nov 06;:
Authors: González-Ramírez LR, Mauro AJ
Abstract
The effect of gap junctions as well as the biological mechanisms behind seizure wave propagation is not completely understood. In this work, we use a simple neural field model to study the possible influence of gap junctions specifically on cortical wave propagation that has been observed in vivo preceding seizure termination. We consider a voltage-based neural field model consisting of an excitatory and an inhibitory population as well as both chemical and gap junction-like synapses. We are able to approximate important properties of cortical wave propagation previously observed in vivo before seizure termination. This model adds support to existing evidence from models and clinical data suggesting a key role of gap junctions in seizure wave propagation. In particular, we found that in this model gap junction-like connectivity determines the propagation of one-bump or two-bump traveling wave solutions with features consistent with the clinical data. For sufficiently increased gap junction connectivity, wave solutions cease to exist. Moreover, gap junction connectivity needs to be sufficiently low or moderate to permit the existence of linearly stable solutions of interest.
PMID: 31696304 [PubMed - as supplied by publisher]

Source: Biological Cybernetics - November 5, 2019 Category: Science Authors: González-Ramírez LR, Mauro AJ Tags: Biol Cybern Source Type: research