Long noncoding RNA DNM3OS promotes prostate stromal cells transformation via the miR-29a/29b/COL3A1 and miR-361/TGF β1 axes.

In conclusion, we identified DNM3OS as a specifically-upregulated lncRNA upon TGFβ1 stimulation in PrSCs; by serving as a ceRNA for the miR-29a/29b cluster and miR-361, DNM3OS eliminated miRNA-mediated suppression of COL3A1 and TGFβ1, thereby promoting TGFβ1-induced PrSC transformation into myofibroblasts.
PMID: 31694982 [PubMed - as supplied by publisher]

Source: Aging - November 5, 2019 Category: Biomedical Science Authors: Wang R, Zhang M, Ou Z, He W, Chen L, Zhang J, He Y, Xu R, Jiang S, Qi L, Wang L Tags: Aging (Albany NY) Source Type: research