FDA Approves Talicia (omeprazole magnesium, amoxicillin and rifabutin) for the Treatment of H. pylori Infection in Adults

TEL-AVIV, Israel and RALEIGH, N.C., Nov. 04, 2019 (GLOBE NEWSWIRE) -- RedHill Biopharma Ltd. (Nasdaq: RDHL) (Tel-Aviv Stock Exchange: RDHL) (“RedHill” or the“Company”), a specialty biopharmaceutical company primarily focused...
Source: Drugs.com - New Drug Approvals - Category: Drugs & Pharmacology Source Type: news

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We report that cholesteryl glucosides in H. pylori activate innate immunity through C-type lectin receptors (CLRs). Cholesteryl acyl α-glucoside (αCAG) was identified as a ligand for Mincle (Clec4e). Upon H. pylori infection, T cell responses and gastritis were ameliorated in Mincle-deficient mice, although bacterial numbers were comparable.Thus the cholesteryl lipid–CLR axis exacerbates H. pylori-induced gastric inflammation with limited contribution to protective immunity.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Conclusion: Ten-day STT was more effective than 7-day STT for HP eradication. The eradication rate was not affected by the CYP2C19 genotype.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Background: Development of gastric diseases like gastritis, peptic ulcer and gastric cancer depends on several biotic and abiotic factors and Helicobacter pylori infection is a well-known biotic factor. However, not all H. pylori-infectedindividuals develop gastric diseases and not all individuals with gastric diseases are infected with H. pylori. Therefore, it is possible that other gastric bacteria also contribute to the formation and progression of gastric diseases.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0554 Source Type: research
scarson The syntheses of six thiol-exhibiting monosaccharides towards suicide inhibition of Helicobacter pylori are reported. Blood group Antigen Binding Adhesin (BabA), a bacterial membrane-bound lectin, binds to human ABO and Lewis b blood group structures displayed on the surface of host epithelial cells. Crystal structures of the carbohydrate-recognition domain revealed a conserved disulfide bonded loop that anchors a critical fucose residue in these blood group structures. Disruption of this loop by N-acetylcysteine results in reduced BabA-mediated adherence to human gastric tissue sections and attenuated virulenc...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ConclusionAlthough the inclusion of five additional clinical trials in this updated meta ‐analysis has not changed the result of the previous review, the current meta‐analysis is superior for having removed one study involving the use of chlorhexidine, which did not meet appropriate criteria for inclusion. Our results strengthen the value of periodontal treatment as an adjunctive re medy. Consistency of these results suggests that the incorporation of professional periodontal treatment with systemic eradication therapy may be a wise strategy, enhancing the efficacy ofH.  pylori eradication therapy.Systematic revie...
Source: International Dental Journal - Category: Dentistry Authors: Tags: CONCISE REVIEW Source Type: research
CONCLUSIONS: The incidence of upper gastrointestinal bleeding due to peptic ulcers and erosions was found to be lower than previously demonstrated in comparable studies, but the overall mortality rate was unchanged. The consumption of risk medication was high, and only a few patients had used prophylactic PPIs. Concurrent H. pylori infection was present in only one-third of the patients. CLINICAL TRIAL REGISTRATION: Bleeding Ulcer and Erosions Study 'BLUE Study', ClinicalTrials.gov Identifier. NCT03367897. PMID: 32931710 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Publication date: 15 September 2020Source: Cell Reports, Volume 32, Issue 11Author(s): Nicole Tegtmeyer, Matthias Neddermann, Judith Lind, Suneesh Kumar Pachathundikandi, Irshad Sharafutdinov, Andrés Julián Gutiérrez-Escobar, Mark Brönstrup, Werner Tegge, Minsun Hong, Manfred Rohde, Robin M. Delahay, Michael Vieth, Heinrich Sticht, Steffen Backert
Source: Cell Reports - Category: Cytology Source Type: research
ConclusionIn conclusion, all these data show thatH.  pylori-induced autophagy is implicated in gastric CSC emergence and could represent an interesting therapeutic target.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
Future Oncology,Volume 16, Issue 26, Page 1997-2006, September 2020.
Source: Future Oncology - Category: Cancer & Oncology Authors: Source Type: research
Abstract OBJECTIVES: The association between Helicobacter pylori and chronic spontaneous urticaria (CSU) is controversial. Therefore, we aimed to directly diagnose H pylori by polymerase chain reaction (PCR) in gastric tissue from patients with CSU and to investigate the association between H pylori eradication therapy and CSU remission. METHODS: Twenty-seven of 72 patients with CSU who were positive for H pylori stool antigen and PCR in gastric biopsy specimens were randomized to receive either anti-H pylori treatment or placebo. RESULTS: Patients with H pylori were found to have significantly lower hem...
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Tags: Am J Clin Pathol Source Type: research
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