Nitro versus Hydroxamate in Siderophores of Pathogenic Bacteria: Effect of Missing Hydroxylamine Protection in Malleobactin Biosynthesis.

Nitro versus Hydroxamate in Siderophores of Pathogenic Bacteria: Effect of Missing Hydroxylamine Protection in Malleobactin Biosynthesis.
Angew Chem Int Ed Engl. 2013 Jul 2;
Authors: Franke J, Ishida K, Ishida-Ito M, Hertweck C
Abstract
The elusive structure of malleobactin, a virulence factor of pathogens belonging to the Burkholderia mallei family, was finally unveiled by genetic and chemical analyses. The novel nitro-substituted siderophore is derived from an unusual, unprotected hydroxylamine, which undergoes spontaneous oxidation, as shown by in vitro assays and detection of analogues featuring hydroxylamino, nitroso, and azoxide groups.
PMID: 23821334 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - July 2, 2013 Category: Chemistry Authors: Franke J, Ishida K, Ishida-Ito M, Hertweck C Tags: Angew Chem Int Ed Engl Source Type: research