Fabrication of biodegradable Mn-doped mesoporous silica nanoparticles for pH/redox dual response drug delivery.

Fabrication of biodegradable Mn-doped mesoporous silica nanoparticles for pH/redox dual response drug delivery. J Inorg Biochem. 2019 Oct 22;202:110887 Authors: Li X, Zhang X, Zhao Y, Sun L Abstract Mn-doped mesoporous silica (MMS) nanocarriers were prepared by in situ doping Mn component for drug delivery. In the acidic or reductive microenvironment of tumor, the MnO bond can be broken up, and Mn components would be released from the silica framework, thus accelerating the degradation of the silica nanocarrier. Due to the mesoporous structure, MMS nanocarriers have a high specific surface area of 1125.56 m2/g, which is suitable for loading and controlled release of drug. And the encapsulation ratio of Dox and drug loading of MMS and MMS/PDA is 98.08%, 39.54% and 38.81% respectively. After loading Dox, polydopamine(PDA)was coated on the surface of MMS nanocarriers to reduce drug burst release and endow them pH-responsive release. The prepared Dox-MMS/PDA delivery system displays pH/redox dual-responsive degradation of carriers and drug release. PMID: 31670257 [PubMed - as supplied by publisher]
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research