Surgical Considerations and Systemic Therapy of Melanoma

This article aims to highlight the current era of integrated multidisciplinary care of patients with advanced melanoma by outlining current approved therapies, including immunotherapy, targeted therapy, radiation therapy, and other strategies used in both the adjuvant and the neoadjuvant setting as well as the evolving role of surgical intervention in the changing landscape of advanced melanoma.
Source: Surgical Clinics of North America - Category: Surgery Authors: Source Type: research

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Publication date: December 2019Source: British Journal of Oral and Maxillofacial Surgery, Volume 57, Issue 10Author(s): James Higginson, Sadiq Mawji, Amit Dattani, Neil Barnard, Keiron McVeigh
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2019Source: British Journal of Oral and Maxillofacial Surgery, Volume 57, Issue 10Author(s): Rhea Chouhan, Raveena Patel, Konstantinos Mitsimponas
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Condition:   Melanoma Intervention:   Drug: Ipilimumab Sponsor:   Bristol-Myers Squibb Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 11 December 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Giusy Elia, Silvia Martina Ferrari, Maria Rosaria Galdiero, Francesca Ragusa, Sabrina Rosaria Paparo, Ilaria Ruffilli, Gilda Varricchi, Poupak Fallahi, Alessandro AntonelliAbstractAnticancer immunotherapy, in the form of immune checkpoint inhibition (ICI), is a paradigm shift that has transformed the care of patients with different types of solid and hematologic cancers. The most notable improvements have been seen in patients with melanoma, non-small-cell lung, bladder, renal, cervical, u...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Current practice in managing regional disease in head and neck melanoma is with a comprehensive neck dissection. The knowledge that this does not afford a survival benefit combined with recent encouraging advances in immunotherapy do raise the question if a lesser procedure such as a selective neck dissection (SND) would be more appropriate. We would like to invite discussion into the prospect of using this treatment in malignant cutaneous melanoma of the head and neck.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Tags: Correspondence and Communications Source Type: research
Authors: Covarelli P, Barberini F, Cannavicci D, Cirocchi R, Rulli A, Boselli C, De Giorgi V Abstract BACKGROUND: Radical lymph nodes dissection (RLND) is the standard procedure for regional control of disease in patients with metastatic melanoma (stage III). Because of its aggressiveness, lymphorrhoea is a constant problem in post-operative. METHODS: In this prospective non randomized study with a retrospective analysis of data, patients undergoing surgical treatment of axillary or iliac-inguinal radical lymph-node dissection (RLND) received standard treatment plus a collagen-fibrin sealant patch (TachoSil) (n...
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
Human Mucosal Melanoma (hMM) is an aggressive neoplasm of neuroectodermal origin with distinctive features from the more common cutaneous form of malignant melanoma (cMM). At the molecular level, hMMs are characterized by large chromosomal aberrations rather than single-nucleotide mutations, typically observed in cMM. Given the scarcity of available cases, there have been many attempts to establish a reliable animal model. In pet dogs, Canine Oral Melanoma (COM) is the most common malignant tumor of the oral cavity, sharing clinical and histological aspects with hMM. To improve the knowledge about COM's genomic DNA alterat...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Neutrophils, as "Trojan horses", participate in the delivery of therapeutical PLGA nanoparticles into a tumor based on the chemotactic effect. Drug Deliv. 2020 Dec;27(1):1-14 Authors: Hao J, Chen J, Wang M, Zhao J, Wang J, Wang X, Li Y, Tang H Abstract Inspired by the fact that leukocytes have innate phagocytic functions and oriented migration capabilities in response to chemoattractants, we have unveiled that endogenous neutrophils as "Trojan horses", participate in the delivery of nanoparticles in an "in vivo self-armed assembly" manner. Neutrophils were the main populat...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
WEDNESDAY, Dec. 11, 2019 -- For nonelderly adults in the United States, having Medicaid or no health insurance is associated with increased odds of being diagnosed with late-stage melanoma compared with having private insurance, according to a study...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
In this study, platinum nanoparticles (PtNPs) were synthesized and applied for cancer therapy upon 808-nm laser light and X-ray radiation, or their combination. Two power densities of laser (1.0 and 1.5 W cm−2) and three X-ray doses (2, 4 and 6 Gy) were selected for irradiation of B16/F10 cell line at 24 and 72 h-post treatment. The synthesized PtNPs had a spherical shape with a diameter of 12.2 ± 0.7 nm, and were cytocompatible up to 250 μg mL−1. A photothermal conversion activity in a concentration-dependent manner at 72 h-post treatment was observed. Also, PtNPs represented cyto...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
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