The impact of ignoring inbreeding in pairwise kinship evaluations

Inbreeding is often ignored in forensic kinship inference, either because the exact genealogies are unknown, or because current methods are inadequate for inbred pedigrees. In many situations, this may be a reasonable simplification, but in other, it can lead to wrong inference of relatedness between two individuals. In order to quantify the impact of ignoring inbreeding, we simulate marker data for a selection of inbred pedigrees, and subject them to pairwise kinship inference using standard noninbred assumptions.

Source: Forensic Science International: Genetics Supplement Series - October 31, 2019 Category: Forensic Medicine Authors: Hilde Kjelgaard Brustad, Thore Egeland Source Type: research