New Automated Immunosuppressive Drug Assays Improve Therapeutic Drug Monitoring for Transplant Patients

For the first time, certain immunosuppressive drug (ISD) assays can now be performed automatically on cobas® modular platforms, allowing laboratories to consolidate testing for a wide range of transplant testing/monitoring assays onto a single platform. The new Roche automated assays for tacrolimus and cyclosporine will enhance therapeutic drug monitoring (TDM) of transplant recipients by providing the consistency and accuracy of an automated assay, while enhancing workflows, auditing and reporting capabilities in the laboratory.
Source: Pharmaceutical Online News - Category: Pharmaceuticals Source Type: news

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Publication date: Available online 5 June 2020Source: Journal of Geriatric OncologyAuthor(s): Smith Giri, Madan Raj Aryal, Han Yu, Alyssa Grimshaw, Ranjan Pathak, Scott P. Huntington, Binod Dhakal
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
AbstractHigh-grade B cell lymphomas withMYC andBCL2 and/orBCL6 rearrangements ( “double-hit” lymphoma (DHL)/“triple-hit” lymphoma (THL)) are mature B cell neoplasms with highly aggressive clinical behavior and poor response to therapy. Lymphoblastic transformation of mature B cell neoplasms is an uncommon event that is best recognized for follicular lymphoma (FL). To ou r knowledge, only one case of “B lymphoblastic” transformation of de novo DHL has been reported in the literature. Here, we describe another case of such transformation. The patient was a 57-year-old man who presented wit...
Source: Journal of Hematopathology - Category: Pathology Source Type: research
In this study, we propose a self-assembled, injectable multicellular microspheres containing human umbilical vein endothelial cells (HUVECs) and mesenchymal stem cell (MSCs), collagen hydrogel (Col), and hFDM toward therapeutic angiogenesis. Those multicellular microspheres are spontaneously formed by the mixtures of cell and hydrogel after being dropped on the parafilm for several hours. The size of microspheres can be manipulated via adjusting the initial volume of droplets and the culture period. The cells in the microspheres are highly viable. Multicellular microspheres show good capability of cell migration on 2D cult...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
Condition:   Hemophilia A Interventions:   Drug: Gene therapy;   Other: Biological Sponsor:   Expression Therapeutics, LLC Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Mind jumble: Understanding chemo brain (Stanford Medicine): Sarah Liu was treated for leukemia as a teenager. She attended her high school graduation on a four-hour pass from Lucile Packard Children’s Hospital Stanford and was bald under her white graduation cap, her arm bandaged where she’d been receiving chemotherapy drugs. Liu survived cancer and the ordeal of her treatment, and for many years she thrived. But today, at 53, she struggles to remember the names of all the Stanford oncologists who helped her, though she reveres them for saving her life. Many years later, her childhood cancer treatments — ...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology astrocyte chemo-brain chemobrain chemotherapy chemotherapy-related cognitive impairment cognitive difficulties Cognitive-impairment microglia myelin oligodendrocyte OPC Source Type: blogs
Data on protocol biopsies (PBs) after pediatric kidney transplantation are rare. We evaluated 6-month post-transplantation renal function in 86 children after PB as observational study. Patients were divided into 3 groups: 1.PB pathological findings absent, no intervention (n = 44);2.pathological findings but stable serum creatinine so no intervention (n = 27);3.pathological findings (borderline rejection (borderline) Banff classification (Banff) Ia or IIa), increased serum creatinine 20%, therapy initiated (n = 15). Glomerular filtration rate (GFR) and delta GFR were determined. 1.Group 1: Mean GFR was 79...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
(University of Colorado Anschutz Medical Campus) Study based on a decade of research and treatment shows no difference in overall survival between cord blood and matched related donor as source for stem cell transplant, with reduced graft-versus-host disease in patients using cord blood.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(ERA-EDTA) The risk of death is relatively high in kidney transplant patients admitted to hospital with COVID-19. Advanced age is the most important risk factor for death but, unlike in the general population, male sex, diabetes and cardiovascular disease do not appear to increase this risk. Younger, healthier patients may not be at special risk if they adhere strictly to hygiene and social distancing advice.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Contributors : Fadi G Lakkis ; Khodor Abou-DayaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAbstract: Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. It is not known however whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously upon a second encounter. Here, we show that murine monocytes and macrophages acquire memory specific to MHC-I antigens and identify paired immunoglobulin-like receptors-A (PIR-A) as the MHC-I receptors necessary for the memory response. We...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
With a potential match arising at the height of the COVID-19 pandemic, Upstate and the patient, Lonel Woods, had to take many extra steps to ensure everyone ’s safety.
Source: SUNY Upstate Medical - Category: Universities & Medical Training Tags: News Source Type: news
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