Cancers, Vol. 11, Pages 1690: Successful Targeting of the Warburg Effect in Prostate Cancer by Glucose-Conjugated 1,4-Naphthoquinones

In conclusion, glucose-conjugated 1,4-naphthoquinones show potent activity and selectivity in human CRPC exerted via mitochondrial targeting. The compounds can overcome drug resistance against current standard therapies and suppress pro-survival mechanisms. This unique combination of properties makes them new promising candidates for the treatment of CRPC.

Source: Cancers - October 29, 2019 Category: Cancer & Oncology Authors: Sergey A. Dyshlovoy Dmitry N. Pelageev Jessica Hauschild Ksenia L. Borisova Moritz Kaune Christoph Krisp Simone Venz Yurii E. Sabutskii Ekaterina A. Khmelevskaya Tobias Busenbender Vladimir A. Denisenko Natalia D. Pokhilo Lyubov N. Atopkina Markus Graefen Tags: Article Source Type: research