Radiation Cystitis: a Contemporary Review

AbstractPurpose of ReviewThere is not a universally agreed upon treatment algorithm for radiation cystitis. The goal of this review will be to discuss numerous options available to the provider at various points in treatment and the literature supporting its use.Recent FindingsThere are various degrees of presentation, with milder forms that can be managed as outpatient and more serious forms requiring inpatient admission. There are a myriad of treatment options, including intravesical instillations, ablative procedures, systemic therapies, hyperbaric oxygen therapy, arterial embolization, and urinary diversion. If these measures are able to control the bleeding in the acute setting, the patient can then be considered for outpatient systemic therapy to decrease the risk of hematuria recurrence. Hyperbaric oxygen therapy has emerged as an outpatient treatment option with very promising results; however, further research needs to evaluate its long-term cost-effectiveness.SummaryRadiation cystitis is a devastating disease process that can occur months to years following radiotherapy and poses many therapeutic challenges. When conservative measures fail to control bladder hemorrhage, arterial embolization or urinary diversion may be ultimately necessary as life-saving measures, however, these are associated with considerable morbidity and mortality. Due to the devastating impact of radiation cystitis on patient quality of life, further research is imperative in order to add furth...
Source: Current Bladder Dysfunction Reports - Category: Urology & Nephrology Source Type: research