Practical and reliable synthesis of 2',3',5',5 ″-tetradeuterated uridine derivatives.

Practical and reliable synthesis of 2',3',5',5″-tetradeuterated uridine derivatives.
Nucleosides Nucleotides Nucleic Acids. 2019 Oct 24;:1-9
Authors: Miyamoto N, Ohno H, Kitamura Y, Park K, Sawama Y, Sajiki H, Kitade Y
Abstract
Deuterated drugs are valuable in the fields of drug discovery and medicinal chemistry. 2',3',5',5″-tetradeuterated uridine derivatives were synthesised from 2,3,5,5'-selectively tetradeuterated ribose using Sajiki's H-D exchanged Ru/C-H2-D2O-NaOH system and silyl-Hilbert-Johnson methods. The total deuterium content of the tetradeuterated uridines was over 92% using either basic or acidic reaction conditions. These derivatives would be expected as building blocks for the synthesis of deuterium-substituted nucleic acid probes for tracking the pharmacokinetics of nucleic acid drugs.
PMID: 31645174 [PubMed - as supplied by publisher]

Source: Nucleosides, Nucleotides and Nucleic Acids - October 26, 2019 Category: Biochemistry Tags: Nucleosides Nucleotides Nucleic Acids Source Type: research