Orbital metastases of invasive lobular breast carcinoma.
Orbital metastases of invasive lobular breast carcinoma. Breast Dis. 2019 Oct 11;: Authors: Tsagkaraki IM, Kourouniotis CD, Gomatou GL, Syrigos NK, Kotteas EA Abstract Breast cancer is the main site of origin of orbital metastatic disease. Although invasive lobular breast carcinoma accounts for 10-15% of all breast cancer cases, it has been noticed that it metastasizes to the orbit more often compared to breast cancer of no special type (NST). The pathogenesis of this metastasis is not entirely understood; however, it seems that the unique tissue-specific characteristics of orbital microenvironment might contribute to metastatic disease in this particular site. Given the increasing survival of breast cancer patients and the prolonged metastatic potential of invasive lobular breast carcinoma, it is possible that the incidence of this rare metastasis might increase in the future. The purpose of this review is to present clinical manifestations, immunohistochemical characteristics and therapeutic options for orbital metastases from invasive lobular carcinoma. PMID: 31640079 [PubMed - as supplied by publisher]
CONCLUSIONS: EPclin provided highly significant prognostic value and significant risk stratification for women with ILC. 10-year DR risk in the EPclin low risk groups were similar between ILC and IDC. Our results show that EPclin is informative in women with ILC and suggest that it is equally valid in both histological subtypes. PMID: 32561662 [PubMed - as supplied by publisher]
CONCLUSION: These findings support the use of prophylactic NSM in high-risk patients. The nipples could be preserved in the majority of patients, postoperative complication rates were low, and, with limited follow-up, there were no new breast cancers. PMID: 32432359 [PubMed - as supplied by publisher]
AbstractCD34+ fibroblasts are constitutive stromal components of virtually all organs, including the mammary stroma, being involved in matrix synthesis, antigen presentation, and tumor-associated stromal remodeling. The most common subtype of invasive breast carcinoma, invasive carcinoma of no special type (IBC-NST), is known for its stromal loss of CD34+ fibroblasts while acquiring alpha smooth muscle actin-positive ( α-SMA+) myofibroblasts, i.e., cancer-associated fibroblasts (CAF), whereas invasive lobular carcinoma (ILC) displays partial preservation of CD34+ fibroblasts. The aim of this study was to evaluate the...
Conclusions: Majority of noises were not reproducible. To add evaluation of reproducibility to conventional reading could be helpful to reduce false-positives without decreasing sensitivity, and can improve diagnostic performance of dbPET.
Conclusions: PET/CT radiomics features could provide predictive value for breast cancer molecular subtyping. More research with large sample size needs to be performed to confirm this. This work was supported by National Natural of Science Foundation of China (No. 81630049)
ConclusionsOur findings demonstrated efficacy and safety to perform NSM as prophylactic surgery with good oncological outcomes and low complication rates in a case series of Brazilian patients.
ConclusionsThe pleomorphic designation in ILC does not have clinical utility and should not be used to determine therapy. Rather, mitotic count identified clear prognostic groups in this cohort of pure ILC.
Authors: Karanis M, Koksal H, Ates E, Dogru O Abstract The aim of this study was to evaluate the clinical importance of fibulin-5, which has been shown to display tumour-promoting and tumour-protective functions in breast lesions. Sixty-two breast cancer patients, 19 patients with fibroadenoma, and 15 healthy breast tissues were enrolled. Forty-seven patients had invasive ductal carcinoma (IDC) (12 of them also had in situ carcinoma DCIS), and 15 had invasive lobular carcinoma (ILC). A scoring system from 0 to 4 was used to evaluate the fibulin-5 staining according to the percentage of stained cells. The median val...
Conclusions We found that some clinicohistopathologic features of poor prognosis had higher elasticity values than those of favorable prognosis.
ta DS, Suñén Amador I Abstract OBJECTIVE: Triple-negative tumors are the most aggressive type of breast cancer. We aimed to analyze the main radiologic and histopathologic factors of these tumors to create a risk profile. MATERIALS AND METHODS: We analyzed data from 140 patients diagnosed with triple-negative breast cancer between January 2007 and December 2016, with follow-up through April 2018. We analyzed the following variables in the breast MRI done for staging: size, necrosis, associated findings, adenopathies, and perfusion and diffusion parameters. We analyzed the following variables in ...