The regulatory role of Myomaker and Myomixer-Myomerger-Minion in muscle development and regeneration.

The regulatory role of Myomaker and Myomixer-Myomerger-Minion in muscle development and regeneration.
Cell Mol Life Sci. 2019 Oct 23;:
Authors: Chen B, You W, Wang Y, Shan T
Abstract
Skeletal muscle plays essential roles in motor function, energy, and glucose metabolism. Skeletal muscle formation occurs through a process called myogenesis, in which a crucial step is the fusion of mononucleated myoblasts to form multinucleated myofibers. The myoblast/myocyte fusion is triggered and coordinated in a muscle-specific way that is essential for muscle development and post-natal muscle regeneration. Many molecules and proteins have been found and demonstrated to have the capacity to regulate the fusion of myoblast/myocytes. Interestingly, two newly discovered muscle-specific membrane proteins, Myomaker and Myomixer (also called Myomerger and Minion), have been identified as fusogenic regulators in vertebrates. Both Myomaker and Myomixer-Myomerger-Minion have the capacity to directly control the myogenic fusion process. Here, we review and discuss the latest studies related to these two proteins, including the discovery, structure, expression pattern, functions, and regulation of Myomaker and Myomixer-Myomerger-Minion. We also emphasize and discuss the interaction between Myomaker and Myomixer-Myomerger-Minion, as well as their cooperative regulatory roles in cell-cell fusion. Moreover, we highlight the areas for exploration of Myomaker and ...

Source: Cellular and Molecular Life Sciences : CMLS - October 22, 2019 Category: Cytology Authors: Chen B, You W, Wang Y, Shan T Tags: Cell Mol Life Sci Source Type: research