A Phase III Multinational Multicenter Investigator-Masked Randomised Active-Controlled Trial Comparing the Efficacy and Safety of DE-130A With Xalatan ® in Patients With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Open-Angle Glaucoma or Ocular Hypertension;   Ocular Surface Disease Interventions:   Drug: DE-130A;   Drug: Xalatan® Sponsor:   Santen SAS Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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AbstractTo prospectively examine the effects of selective laser trabeculoplasty (SLT) on the anterior chamber angle (ACA) and its related parameters using anterior segment-optic coherence tomography (AS-OCT). Fifty eyes of 50 patients with primary open angle glaucoma (POAG) and ocular hypertension were included in the study. AS-OCT was performed before SLT application, immediately after and at 1 day and 1 month. Intraocular pressure (IOP), central corneal thickness (CCT) and anterior chamber depth (ACD) were also recorded and evaluated. No statistically significant difference was determined in ACA and other AS-OCT paramete...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conditions:   Glaucoma, Primary Open Angle;   Ocular Hypertension Interventions:   Drug: Study Treatment 1 WB007;   Drug: Study Treatment 2 WB007;   Drug: Study Treatment 3 WB007;   Drug: Timolol 0.5% Sponsor:   Whitecap Biosciences, LLC Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Sinha S, Lee D, Kolomeyer NN, Myers JS, Razeghinejad RM Abstract Introduction: Reduction of intraocular pressure (IOP) is the only known modifiable risk factor for prevention and treatment of glaucoma. Rho-kinase (ROCK) inhibitors are a new class of glaucoma medications introduced recently with novel mechanisms of action and favorable safety profiles. Latanoprost, a common first line drug used for treatment of glaucoma, does not adequately control pressures in all cases. Addition of more than one anti-glaucoma medication affects patient compliance and adherence. Fixed-combination eye drops are combina...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: Available online 30 October 2019Source: Journal of Molecular StructureAuthor(s): Arlinda Bytyqi-Damoni, Ali Kestane, Parham Taslimi, Burak Tüzün, Mustafa Zengin, Hayriye Genc Bilgiçli, ─░lhami GulcinAbstractCarvacrol, as a natural product used for many years in the treatment of various diseases, therefore it was chosen as the starting compound for this study. Novel carvacrol based new oxypropanolamine derivatives were synthesized and characterized by spectroscopic methods. All new compounds were tested as metabolic enzyme inhibitory agents. Their clinical usage of carvacrol has been estab...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Conclusions: Elevations in CVP significantly increased IOP in patients with SV who underwent the Glenn or Fontan procedure. IOP needs to be carefully monitored in the postoperative period after both procedures.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
Most cough/cold preparations contain sympathomimetic decongestants; many contain sedating antihistamines. Adverse effects, including death in children under 2, primarily from decongestants, but also from sedating antihistamines and dextromethorphan prompted FDA to recommend OTC cough and cold products not be used in this group. This, combined with manufacturer withdrawal under age 4, has created a cough and cold market void for young children in the US. Also, decongestant adverse effects in adults, including increased blood pressure, irregular heartbeat, and chest tightness resulted in contraindication in heart disease, hi...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
AbstractPurposeTo investigate the intraocular pressure (IOP)-lowering efficacy and tolerance of brinzolamide/brimonidine fixed combination (BBFC) under real-life conditions in a tertiary glaucoma centre.MethodsMedical records of all ocular hypertensive and open-angle glaucoma patients (n  =  52) treated with BBFC were retrospectively analysed.ResultsThirty-nine patients had primary open-angle, 6 exfoliative, 2 pigment, 1 normal tension and 1 juvenile open-angle glaucoma and 3 ocular hypertension. The prior therapy was a prostaglandin analogue (PG) (n  =  4), PG/timolol (n  =  20), ...
Source: International Ophthalmology - Category: Opthalmology Source Type: research
Idiopathic intracranial hypertension, space-flight associated neuro-ocular syndrome (SANS), and glaucoma are conditions that are among a spectrum of cerebrospinal fluid (CSF)-related ophthalmologic disease. This implies that local CSF pressures at the level of the optic nerve are involved to variable extent in these disease processes. However, CSF pressure measurements are problematic due to invasiveness and interpretation. The pressure measured by a lumbar puncture is likely not the same as the orbital CSF pressure. It is believed this is at least in part due to the flow restrictive properties of the optic canal. To inves...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This study reports a significant increase in the levels of autotaxin, lysophosphatidylcholine (LPC), LPA and connective tissue growth factor (CTGF) in the AH of Caucasian and African American open angle glaucoma patients relative to age-matched non-glaucoma patients. Treatment of human TM cells with dexamethasone, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) increased the levels of autotaxin protein, a response that was mitigated by inhibitors of glucocorticoid receptor, NF-kB and SMAD3. Dexamethasone, TNF-α, IL-1β and LPC treatment of TM cells also led to an increase in the l...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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