A Multi-center RCT Study on the Efficacy and Mechanism of Multi-channel tDCS in Rehabilitation of Cognitive Function After Stroke

Condition:   Cognitive Dysfunction Interventions:   Device: multi-channel tDCS;   Device: single-channel tDCS Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conclusions In 10-km road races, injury rates are low compared with longer races in similar weather conditions. Common medical issues can be managed with basic resources in the on-site medical tent. Green flag start race conditions may not predict race safety with regard to exertional heat stroke risk. There were no deaths in nearly 100,000 finishers.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
Sickle cell disease (SCD) is the most commonly inherited genetic blood disorder, affecting nearly 100,000 children and adults in the United States. Three million Americans carry the sickle cell trait and it is nearly25 times more common in people of African American descent. The disorder, which can cause irregularly shaped blood cells to get stuck in narrow vessels, inflicts substantial pain on patients. The resulting reduced oxygen flow creates life-threatening complications such as difficulty breathing, chest pains, blood clots and stroke.
Source: The Catalyst - Category: Pharmaceuticals Authors: Tags: Research and Development Rare Diseases Pelosi Plan Source Type: news
Matthew O'Conner presented at Undoing Aging earlier this year on the startup biotech company Underdog Pharmaceuticals. The company is spinning out of the SENS Research Foundation (SRF), based on research conducted by the scientific team there in recent years. The company is focused on a class of molecule known cyclodextrins, and have candidates capable of efficiently binding and sequestering 7-ketocholesterol. This form of oxidized cholesterol is of great importance to the progression of atherosclerosis, and possibly other age-related conditions as well. In the case of atherosclerosis, the presence of oxidized cholesterols...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
Publication date: Available online 14 November 2019Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Zhengbao Zhu, Aili Wang, Daoxia Guo, Xiaoqing Bu, Tan Xu, Chongke Zhong, Yanbo Peng, Tian Xu, Hao Peng, Jing Chen, Zhong Ju, Deqin Geng, Jiang He, Yonghong ZhangBackground and AimsHigh serum hepatocyte growth factor (HGF) levels increase the risk of ischemic stroke and are probably associated with outcomes after ischemic stroke. However, it remains unclear whether the association between HGF and ischemic stroke prognosis is modified by blood lipid status.Methods and ResultsData were derived from the CATIS ...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Abstract Sigma 1 receptor (σ1), a small transmembrane protein expressed in most human cells participates in modulating the function of other membrane proteins such as G protein coupled receptors and ion channels. Several ligands targeting this receptor are currently in clinical trials for the treatment of Alzheimer's disease, ischemic stroke and neuro-pathic pain. Hence, this receptor has emerged as an attractive target for the treatment of neuro-pathological diseases with unmet medical needs. It is of interest to identify and characterise novelσ1 receptor ligands with different chemical scaffolds usin...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
Conclusion: This meta-analysis provides evidence that OH was associated with worse cognition. OH accounted for a 30% increase in the risk of dementia and a 36% increase in the risk of stroke. PMID: 31718311 [PubMed - as supplied by publisher]
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Conditions:   Sleep Apnea Syndromes;   Cerebral Infarction Interventions:   Drug: Trazodone;   Drug: Placebo oral tablet Sponsor:   Chang Gung Memorial Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ischemic Stroke Interventions:   Other: Carotid duplex+/- MRA neck;   Other: brain MRA+/-CT angio on carotid and brain;   Other: MRI brain;   Other: DSA (digital subtraction angiography) Sponsor:   Mansoura University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Stroke Interventions:   Device: GEO;   Device: GEO and HUNOVA Sponsor:   Fondazione Don Carlo Gnocchi Onlus Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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