Alterations of Proximal Tubular Secretion in Autosomal Dominant Polycystic Kidney Disease.

CONCLUSIONS: Patients with ADPKD and preserved and reduced GFR demonstrate lower tubular secretory solute excretion compared with healthy controls and patients with non-ADPKD CKD. Our results suggest that tubular secretion is impaired in ADPKD independent of GFR.
PMID: 31628117 [PubMed - as supplied by publisher]

Source: Clinical Journal of the American Society of Nephrology : CJASN - October 17, 2019 Category: Urology & Nephrology Authors: Wang K, Zelnick LR, Chen Y, Hoofnagle AN, Watnick T, Seliger S, Kestenbaum B Tags: Clin J Am Soc Nephrol Source Type: research