Photo-luminescent chiral Carbon-dot@Eu(D-Cam) nanocomposites for selectively luminescence sensing of L-phenylalanine

Publication date: Available online 12 October 2019Source: Journal of Molecular StructureAuthor(s): Jian Zhong Huo, Xin Shu Li, Jun Dan An, Le Xi Zhang, Yong Li, Gui Xiang Du, Xiang Xia Wu, Yuan Yuan Liu, Bin DingAbstract:Currently the detection of L-phenylalanine is quite important in clinicians, which can be applied as a simple quantitative method to diagnose phenylketonuria, a common inherited disorder of amino acid metabolism. In this work, a novel chiral fluorescence hybrid probe CDs@Eu(D-cam) [CDs = Carbon-dot; D-cam = (1R, 3S)-(+)-Camphoric acid] can be successfully prepared through the encapsulation of the ultra-small carbon dots into the chiral Eu(D-cam) coordination framework to prepare the hybrid luminescent composites. The as-prepared fluorescent probe possesses good optical properties and solvent-stability, which has the potential to serve as a chemical sensor. The CDs@Eu(D-cam) fluorescent probe behaves good liner response to L-phenylalanine (L-phe) ranging from 3.3 to 27.532 mg/L and the detection limit is 0.00703 mg/L (S/N = 3). The current detection method can be successfully developed into the real sample discrimination of L-phenylalanine in urine.
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research