Advances in Hair Transplantation Technology: Multiphasic Device for Follicular Unit Excision.

Advances in Hair Transplantation Technology: Multiphasic Device for Follicular Unit Excision. Skinmed. 2019;17(4):241-246 Authors: Gupta AK, Love RP, Mohebi P, Trivellini R Abstract Follicular unit excision (FUE) requires the careful excision of hair-bearing follicular units. The follicle can only be detached from the skin once the epidermis, dermis, and subcutaneous tissues are cut, and each layer requires a different amount of force. Traditional FUE devices can be set only to a single speed during a single excision. The Trivellini Device is a first-in-class programmable multiphasic device that is able to accommodate the cutting of various layers of tissue in a single program, while ensuring minimal transection of hair grafts. We detail the advances in the field of motorized FUE embodied by the multiphasic devices. PMID: 31627785 [PubMed - in process]
Source: Skinmed - Category: Dermatology Authors: Tags: Skinmed Source Type: research

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In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: MSC can be divided into immune-tolerant and pro-rejection types in organ transplantation and Netrin-1 can induce the transformation of MSC from the pro-rejection to immune-tolerant type and markedly prolong the skin graft survival time. PMID: 31696460 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Researchers continue to take incremental steps towards the creation of engineered living tissues containing the vascular networks needed to support it. Absent blood vessels, numerous varieties of functional tissue can be generated from cell samples: lung, liver, kidney, and so forth. These organoids are limited in size to a few millimeters, however, the distance the nutrients and oxygen can perfuse. Generating blood vessel networks is a serious technical challenge, and the major obstacle to the production of entire organs for transplantation. Consider that natural capillary networks exhibit a density of hundreds of vessels...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Purpose of review Vascularized composite allotransplantation (VCA), a life-enhancing treatment for patients with complex tissue defects, trauma or illness, expounds upon the foundation of solid organ transplantation (SOT), the gold standard in end-stage organ failure. As innate and adaptive immunity remain the fundamental concern, this review highlights divergent immunobiology responses in VCA and SOT recipients. Recent findings Host innate immune activation drives peritransplant tissue ischemia–reperfusion injury (IRI). Despite the direct relationship between ischemia–reperfusion (IR)-stress and cell-medi...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: VASCULARIZED COMPOSITE ALLOTRANSPLANTATION: Edited by Linda C. Cendales Source Type: research
Researchers from Rensselaer Polytechnic Institute have developed a new method to 3D print living skin with built-in blood vessels. This living skin construct is cultured in vitro and develops into an interconnected microvascular network underneath a ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Dermatology Materials Medicine Plastic Surgery Rehab Vascular Surgery Source Type: blogs
Reconstruction of upper eyelid defects should aim for a moveable lid with perfect corneal protection and good aesthetic quality. Numerous procedures to reconstruct large upper eyelid defects have been reported, but these methods require 2-stage procedures. A new method for reconstructing full-thickness upper eyelid defects after tumor excision in a single stage was presented in this study. The preferred technique uses excess skin as an advancement flap together with an ear cartilage graft for the lining. Reconstruction was performed with an advancement flap using excess skin and ear cartilage for full-thickness defects aft...
Source: Journal of Craniofacial Surgery - Category: Surgery Tags: Technical Strategies Source Type: research
Chronic graft-versus-host disease (GVHD) is a relatively common complication of allogeneic hemopoietic stem cell transplants (HSCT). Clinical manifestations of chronic GVHD include skin involvement, dry mucosae with ulcerations, gastrointestinal and pulmonary involvement.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
AbstractAllogeneic transplantation of hematopoietic stem cells (allo-HCT) represents an increasingly employed therapeutic approach to potentially cure patients suffering from life-threatening malignant and autoimmune disorders. Despite its lifesaving potential, immune-mediated allo-reactivity inherent to the allogeneic transplantation can be observed within up to 50% of all allo-HCT patients regularly resulting in the manifestation of acute and/or chronic graft-versus-host disease (GvHD). Mechanistically, especially donor T cells are assumed to chiefly drive inflammation that can occur in virtually all organs, with the ski...
Source: Seminars in Immunopathology - Category: Pathology Source Type: research
Conclusions. Graft skin and urethral lining tissue are first rejection targets followed by tunica albuginea and corpora cavernosa in a distal to proximal pattern. We established a robust and reproducible murine model to study the immunobiology of male genital tissue in the context of transplantation and developed a novel 4-grade clinical and histological rejection scale based on graft skin and urethral lining as the main targets of rejection.
Source: Transplantation - Category: Transplant Surgery Tags: Original Basic Science–General Source Type: research
BOSTON (CNN) — Robert Chelsea just got a new face, and with it, he is the latest milestone in the burgeoning world of facial transplant surgery. He is the first African American to receive a full facial transplant, with a successful surgery at Brigham and Women’s Hospital in Boston. A black patient in Paris received a partial face transplant in 2007. At 68 years old, he’s the oldest person to undergo the surgery as well. “It’s a great wonder,” Chelsea told CNN in a phone interview on Friday. “This whole process gave me a whole new dimension on seeing myself.” After the standa...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Offbeat Syndicated CBSN Boston Brigham and Women's Hospital Source Type: news
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