Bleeding disorders in adolescents with heavy menstrual bleeding in a multicentre prospective US cohort.

Bleeding disorders in adolescents with heavy menstrual bleeding in a multicentre prospective US cohort. Haematologica. 2019 Oct 17;: Authors: Zia A, Jain S, Kouides P, Zhang S, Gao A, Salas N, Lau M, Wilson E, DeSimone N, Sarode R Abstract Heavy menstrual bleeding is common in adolescents. The frequency and predictors of bleeding disorders in adolescents, especially with anovulatory bleeding, are unknown. Adolescents referred for heavy menstrual bleeding underwent an evaluation of menstrual bleeding patterns, and bleeding disorders determined a priori. The primary outcome was the diagnosis of a bleeding disorder. Two groups were compared: anovulatory and ovulatory bleeding. Multivariable logistic regression analysis of baseline characteristics and predictors was performed. Kaplan Meier curves were constructed for the time from the first bleed to bleeding disorder diagnosis. In two-hundred adolescents, a bleeding disorder was diagnosed in 33%(n=67): Low von Willebrand factor levels in 16%; von Willebrand disease in 11% and qualitative platelet dysfunction in 4.5%. The prevalence of bleeding disorder was similar between ovulatory and anovulatory groups (31% vs. 36%; p=0.45). Predictors of bleeding disorder included: younger age at first bleed (OR:0.83; 95% CI:0.73,0.96), Hispanic ethnicity (OR:2.48; 95%CI: 1.3,5.05), non-presentation to emergency department for heavy bleeding (OR:0.14; 95%CI:0.05,0.38) and ISTH-Bleeding Assessment Tool...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research