Discovery and Contribution of Nontypeable Haemophilus influenzae NTHI1441 to Human Respiratory Epithelial Cell Invasion [Molecular Pathogenesis]

This study reveals NTHI1441 as a novel NTHi virulence factor expressed during infection of the COPD lower airways that contributes to invasion of host respiratory epithelial cells. The role in host cell invasion, conservation among strains, and expression of surface-exposed epitopes suggest that NTHI1441 is a potential target for preventative and therapeutic interventions for disease caused by NTHi.

Source: Infection and Immunity - October 17, 2019 Category: Infectious Diseases Authors: Ahearn, C. P., Kirkham, C., Chaves, L. D., Kong, Y., Pettigrew, M. M., Murphy, T. F. Tags: Molecular Pathogenesis Source Type: research