The immunoglobulin γ marker 17 allotype and KIR/HLA genes prevent the development of chronic hepatitis B in humans.

The immunoglobulin γ marker 17 allotype and KIR/HLA genes prevent the development of chronic hepatitis B in humans. Immunology. 2019 Oct 15;: Authors: Di Bona D, Pandey JP, Aiello A, Bilancia M, Candore G, Caruso C, Colomba C, Duro G, Ligotti ME, Macchia L, Rizzo S, Accardi G Abstract Hepatitis B virus (HBV) infection causes a self-limiting disease in most individuals. However, <10% of infected subjects develop a chronic disease. Genetic host variability of polymorphic genes at the interface of innate and acquired immunity, such as killer immunoglobulin-like receptors (KIR), their human leucocyte antigen (HLA), and IgG allotypes (GM) could explain this different clinical picture. We previously showed a protective role of the KIR2DL3 gene for the development of chronic hepatitis B (CHB) and a detrimental role of the KIR ligand groups, HLA-A-Bw4 and HLA-C2. We have expanded the previous analysis genotyping patients for GM23 and GM3/17 allotypes. The comparison of the patients with CHB with those who resolved HBV infection showed that the presence of GM17 allele virtually eliminated the risk of developing CHB (OR, 0.03; 95%CI, 0.004-0.16; p<0.0001). In addition, the combination of GM17, KIR2DL3, HLA-A-Bw4, and HLA-C2 was highly sensitive to predict the outcome of HBV infection. PMID: 31613998 [PubMed - as supplied by publisher]
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research