Sensors, Vol. 19, Pages 4476: Point-of-Care Strategies for Detection of Waterborne Pathogens

Sensors, Vol. 19, Pages 4476: Point-of-Care Strategies for Detection of Waterborne Pathogens Sensors doi: 10.3390/s19204476 Authors: Sandeep Kumar Monika Nehra Jyotsana Mehta Neeraj Dilbaghi Giovanna Marrazza Ajeet Kaushik Waterborne diseases that originated due to pathogen microorganisms are emerging as a serious global health concern. Therefore, rapid, accurate, and specific detection of these microorganisms (i.e., bacteria, viruses, protozoa, and parasitic pathogens) in water resources has become a requirement of water quality assessment. Significant research has been conducted to develop rapid, efficient, scalable, and affordable sensing techniques to detect biological contaminants. State-of-the-art technology-assisted smart sensors have improved features (high sensitivity and very low detection limit) and can perform in a real-time manner. However, there is still a need to promote this area of research, keeping global aspects and demand in mind. Keeping this view, this article was designed carefully and critically to explore sensing technologies developed for the detection of biological contaminants. Advancements using paper-based assays, microfluidic platforms, and lateral flow devices are discussed in this report. The emerging recent trends, mainly point-of-care (POC) technologies, of water safety analysis are also discussed here, along with challenges and future prospective applications of these smart sensing technologies for water health diagnostics...
Source: Sensors - Category: Biotechnology Authors: Tags: Review Source Type: research

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Publication date: Available online 19 November 2019Source: International Journal of PharmaceuticsAuthor(s): Leonie Wagner-Hattler, Gabriela Québatte, Jennifer Keiser, Joachim Schoelkopf, Christian M. Schlepütz, Jörg Huwyler, Maxim PuchkovAbstractUniform drug distribution within fast disintegrating tablets is a key quality measure to ensure a reliable, steady, and targeted release of the contained active pharmaceutical ingredients. In this work, the drug particle distribution in mini-tablets was studied with synchrotron phase contrast X-ray microtomography. Mini-tablets had a weight of 9.5 mg and a drug loa...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
This study aimed to provide data on the occurrence, genetic characterization, and epidemiological significance of Sarcocystis spp. in cattle destined for human consumption in Romania. A total of 117 heart samples from slaughtered cattle in three southwestern Romanian counties (Dolj, Timiș, and Gorj) were analyzed in order to detect sarcocysts, using fresh examination microscopic techniques. Subsequently, the isolated sarcocysts and/or cyst fragments (5-15 per sample) from each infected animal were molecularly characterized. Overall, 17.9% (21/117) of the tested animals were found to be Sarcocystis spp. positive by microsc...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract Background: Leishmaniasis is an infectious disease caused by an intracellular parasite of Leishmania and is transmitted through the female sandflies bite and may lead to severe skin lesions. Although drugs such as antimony compounds are available, their side effects such as toxicity, low efficacy, and emergence of resistance have raised the importance of effective replacement. Imatinib, as an inhibitor of tyrosine kinase (TK) of Leishmania, stops abnormal function of TK such as Bcr-Abl through assembling into transmembrane pores in a sterol-dependent manner. Hence, the evaluation of killing effects of dif...
Source: Biomed Res - Category: Research Authors: Tags: Adv Biomed Res Source Type: research
Human African trypanosomiasis (HAT) caused by the extracellular protozoon Trypanosoma brucei, is a neglected tropical disease affecting the poorest communities in sub-Saharan Africa. HAT progresses from a hemolymphatic first stage (S1) to a meningo-encephalitic late stage (S2) when parasites reach the central nervous system (CNS), although the existence of an intermediate stage (Int.) has also been proposed. The pathophysiological mechanisms associated with the development of S2 encephalopathy are yet to be fully elucidated. Here we hypothesized that HAT progression toward S2 might be accompanied by an increased release of...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In conclusion, Trypanosoma species express a copper-transporting P1B-1-type ATPase and together with other copper-binding proteins identified in the genomes of kinetoplastid parasites may constitute potential targets for anti-trypanosomal drug discovery.Graphical abstract
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
Publication date: Available online 19 November 2019Source: Veterinary ParasitologyAuthor(s): Ana Huertas-López, Carlos Martínez-Carrasco, José Joaquín Cerón, Roberto Sánchez-Sánchez, Ángela Vázquez-Calvo, Gema Álvarez-García, Silvia Martínez-SubielaAbstractNeospora caninum is a protozoan parasite (Phylum Apicomplexa) that has been recently suggested as a relevant cause of reproductive disorders in small ruminants. The aim of the present study is to develop and validate a new serological test based on time resolved fluorescency using N. cani...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Neurodegenerative conditions are largely characterized by the aggregation of a few altered proteins that are prone to forming solid deposits in and around neurons. Tissues, such as the brain, made up of long-lived cells, such as neurons, are particularly vulnerable to this sort of dysfunction, as they cannot dilute harmful protein aggregates by cell division, and dysfunctional cells are not readily destroyed and replaced. Cells must rely upon internal quality control mechanisms such as the presence of chaperone proteins responsible for chasing down misfolded or otherwise problematic proteins, and ensuring they are refolded...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Conclusions: Enteropathogen infections were common around the time of rotavirus vaccination in rural Zimbabwean infants but did not explain poor RVV immunogenicity and were not reduced by a package of household-level WASH interventions.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
WARNING, GRAPHIC CONTENT: Jashu Patel, from Virar Town, near Mumbai, sought medical help after suffering severe pain and itchiness in his right eye for two months.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Of 56 tested soups, at least five had abilities to curb parasite growth, the study led by Imperial College London showed. The responsible ingredient in the soups is unclear.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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