The Phytocannabinoid ( –)-Cannabidiol Operates as a Complex, Differential Modulator of Human Hair Growth: Anti-Inflammatory Submicromolar versus Hair Growth Inhibitory Micromolar Effects

Most cases of excessive hair loss and unwanted hair growth (e.g., effluvium, alopecia, hirsutism, hypertrichosis) result in part from major disturbances in the cyclic transformation of hair follicles (HFs), namely in their switch from active growth and pigmented hair shaft production (anagen) to apoptosis-driven HF involution (catagen) (Oh et  al., 2016; Paus and Cotsarelis, 1999). It is now clear that this switch is profoundly influenced by complex neuroendocrine pathways, which still await systematic therapeutic targeting (Paus et al., 2014).

Source: Journal of Investigative Dermatology - July 28, 2019 Category: Dermatology Authors: Imre L. Szab ó, Erika Lisztes, Gabriella Béke, Kinga Fanni Tóth, Ralf Paus, Attila Oláh, Tamás Bíró Tags: Letters to the Editor Source Type: research