A 15-Year-Old Girl with a Squint
A 15-year-old girl from Singapore presented with 1-week history of blurry vision. She described seeing objects alongside each other horizontally, with no changes in color perception. She had no intercurrent illnesses or preceding head injury. There were no chronic early morning headaches or nausea. There was no family history of autoimmune conditions.
Conclusion: When treating children with cyclic strabismus, the best surgical results can be achieved when surgery is planned according to the amount of deviation on the strabismic day. PMID: 31746262 [PubMed - as supplied by publisher]
Authors: Hering E PMID: 31746253 [PubMed - as supplied by publisher]
Conclusion: Parenting stress is an additional pathway connecting maternal trait anxiety and children's externalizing and internalizing behavior problems. The risk for child externalizing problems conveyed by elevated maternal trait anxiety and parenting stress may be buffered by better self-regulation in 4-year-olds. These results suggest that interventions that include decreasing parenting stress and enhancing child self-regulation may be important to limiting the transgenerational impact of maternal trait anxiety.
Authors: Kaur U, Pathak BK, Singh A, Chakrabarti SS Abstract The motive of this article is to review the pharmacological and clinical aspects of esketamine (ESK), an NMDA-receptor antagonist approved recently by the FDA for treatment-resistant depression (TRD). PubMed/Medline database was searched using keywords 'esketamine' and 'depression', 'S-ketamine' and 'depression', and 'NMDA antagonist' and 'depression'. Individual trials were searched from ClinicalTrials.gov. We included English-language articles evaluating pharmacokinetics and pharmacodynamics of intranasal (IN) esketamine, along with clinical trial data ...
In conclusion, the present study identified the splicing mutation c.360+5G>T in the GPR143 gene in a Chinese family with OA1 and successfully identified the site. To the best of our knowledge, there have been no previous reports regarding this mutation in any major genome databases; therefore, this outcome may enrich the mutation spectrum of the GPR143 gene. PMID: 31746431 [PubMed - as supplied by publisher]
This study reaffirms the theory-practice gap phenomenon. This signifies the need for closer collaboration between educational, healthcare industry and regulatory stakeholders to examine and address factors that influence their transition experience to better support them for workforce readiness.
Conclusions: Patients who fell were not wearing hip or head protection. Most falls were unwitnessed, and none were on 1:1 observation. Such interventions may help prevent future injurious falls.
Authors: Rapoport AM, Lin T Abstract Introduction: Non-invasive neuromodulation devices represent an emerging field in the acute treatment of migraine. High efficacy, favorable safety profile, good tolerability and low cost are important factors for the desired shift to non-pharmacological treatments. This will have the potential to improve the quality of life of people with migraine and reduce the risk for adverse events and medication overuse headache (MOH).Areas covered: Nerivio™ (Theranica Bio-Electronics, Israel) is a novel FDA-cleared remote electrical neuromodulation (REN) device for acute treatment of...
Conditions: Obesity; Diabetes; Diet, Healthy Interventions: Behavioral: Healthier Choice Symbol; Behavioral: Physical Activity Equivalent label Sponsors: Duke-NUS Graduate Medical School; National Medical Research Council (NMRC), Singapore Completed