Glycogen synthase kinase 3 β hyperactivity in urinary exfoliated cells predicts progression of diabetic kidney disease.

Burgeoning evidence points to glycogen synthase kinase (GSK)3 β as a key player in diverse kidney diseases. However, as a pivotal transducer of the insulin signaling pathway, the role of GSK3β in diabetic kidney disease remains uncertain. In db/db mice, renal expression of total and activated GSK3β was increasingly elevated. This preceded the development of diabetic kidney disease, and correlated with the progression of signs of diabetic kidney injury, including albuminuria and extracellular matrix accumulation in glomeruli and tubulointerstitia.

Source: Kidney International - October 9, 2019 Category: Urology & Nephrology Authors: Xianhui Liang, Pei Wang, Bohan Chen, Yan Ge, Athena Y. Gong, Bryce Flickinger, Deepak K. Malhotra, Li Juan Wang, Lance Dworkin, Zhangsuo Liu, Rujun Gong Tags: Clinical Investigation Source Type: research