Automated microfluidic chip system for radiosynthesis of PET imaging probes.

Automated microfluidic chip system for radiosynthesis of PET imaging probes.
J Zhejiang Univ Sci B. 2019 Nov.;20(11):865-867
Authors: Lei M, Pan JZ, Xu GM, Du PZ, Tian M, Zhang H
Abstract
Positron emission tomography (PET) is a powerful non-invasive molecular imaging technique for the early detection, characterization, and "real-time" monitoring of disease, and for investigating the efficacy of drugs (Phelps, 2000; Ametamey et al., 2008). The development of molecular probes bearing short-lived positron-emitting radionuclides, such as 18F (half-life 110 min) or 11C (half-life 20 min), is crucial for PET imaging to collect in vivo metabolic information in a time-efficient manner (Deng et al., 2019). In this regard, one of the main challenges is rapid synthesis of radiolabeled probes by introducing the radionuclides into pharmaceuticals as soon as possible before injection for a PET scan. Although many potential PET probes have been discovered, only a handful can satisfy the demand for a highly efficient synthesis procedure that achieves radiolabeling and delivery for imaging within 1-2 radioisotope half-lives. Only a few probes, such as 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) and [18F]fluorodopa, are routinely produced on a commercial scale for daily clinical diagnosis (Grayson et al., 2018; Carollo et al., 2019).
PMID: 31595722 [PubMed - in process]

Source: J Zhejiang Univ Sci ... - October 10, 2019 Category: Science Authors: Lei M, Pan JZ, Xu GM, Du PZ, Tian M, Zhang H Tags: J Zhejiang Univ Sci B Source Type: research