Detection of exhaled gas by γ-graphyne and twin-graphene for early diagnosis of lung cancer: A density functional theory study

Publication date: Available online 8 October 2019Source: Physics Letters AAuthor(s): Roya Majidi, Marzieh NadafanAbstractIn lung cancer, primary diagnosis is quite essential to guarantee human health. In this work, the capability of γ-graphyne and twin-graphene sheets to detect typical breath gases such as benzene, styrene, aniline, and o-toluidine is studied based on density functional theory. The results indicate that these gases are physisorbed on γ-graphyne and twin-graphene. Because of relatively low gas binding strength between gases and γ-graphyne and twin-graphene, these sheets can be proper for the practical gas sensors with a fast recovery rate. Both γ-graphyne and twin-graphene have semiconducting properties before and after gas adsorption. Adsorption of the gases decreases the energy band gap, and increases the electric dipole moment of γ-graphyne and twin-graphene. The electronic properties of twin-graphene are more sensitive than that of γ-graphyne to the presence of the considered gases. Hence, twin-graphene can be desirable and promising material for sensing typical breath gases to diagnose lung cancer.
Source: Physics Letters A - Category: Physics Source Type: research

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SummaryAnaplastic lymphoma kinase (ALK), which belongs to the insulin receptor tyrosine kinase superfamily, plays an important role in nervous system development. Due to chromosomal translocations, point mutations, and gene amplification, constitutively activated ALK has been implicated in a variety of human cancers, including anaplastic large-cell lymphoma (ALCL), non-small cell lung cancer, and neuroblastoma. We evaluated the anti-cancer activity of the ALK inhibitor KRCA-0008 using ALCL cell lines that express NPM (nucleophosmin)-ALK. KRCA-0008 strongly suppressed the proliferation and survival of NPM-ALK-positive ALCL ...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 18 January 2020Source: Seminars in Cancer BiologyAuthor(s): Zhenchang Wang, Kangkang Zhi, Zhongyang Ding, Yi Sun, Shuang Li, Manyuan Li, Kefeng Pu, Jun ZouAbstractCancer has thwarted as a major health problem affecting the global population. With an alarming increase in the patient population suffering from diverse varieties of cancers, the global demographic data predicts sharp escalation in the number of cancer patients. This can be expected to reach 420 million cases by 2025. Among the diverse types of cancers, the most frequently diagnosed cancers are the breast, colorectal, prostate ...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: Atezolizumab is more efficient and more costly than docetaxel in the 2nd line treatment of NSCLC of stage IIIB or IV, in France, with results consistent to previous French authorities' evaluation of immunotherapies in similar indication. Lastly, atezolizumab is a cost saving alternative to nivolumab, based on list price. PMID: 31951770 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
ConclusionsLung cancer surgery for HD patients provides favorable long-term outcomes despite higher postoperative mortality and morbidity rates. As an extended operation is significantly associated with postoperative complications, thoracic surgeons should carefully select the type of resection based on a balance between the therapeutic benefit and invasiveness in these patients.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Abstract RNA molecules carry diverse modifications that exert important influences in many cellular processes. In addition to the single modification occurring in either nucleobase or 2' hydroxyl of ribose in RNA, some dual modifications occur in both the nucleobase and 2' hydroxyl of ribose in RNA. 2'-O-methyl-5-methylcytidine (m5Cm), the dual modifications of cytidine, was first discovered from the tRNA of archaea. Recent studies identified that 2'-O-methyl-5-hydroxymethylcytidine (hm5Cm) and 2'-O-methyl-5-formylcytidine (f5Cm) were present in the anticodon of cytoplasmic tRNA of mammals. Similar to the series o...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
ConclusionThis is the first report on the synthesis of two novel ginsenosides, namely, glucosyl ginsenoside Rh2 and diglucosyl ginsenoside Rh2 from Rh2 by using recombinant GT isolated from L. rhamnosus. Moreover, diglucosyl ginsenoside Rh2 might be a new candidate for treatment of inflammation, obesity, and skin whiting, and especially for anticancer.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
In this study, compound Liuju formula was taken as an example to isolate compounds with synergistic biological activity through systems pharmacology strategy. Through pharmacokinetic evaluation, 37 potentially active compounds were screened out. Meanwhile, 116 targets of these compounds were obtained by combing with the target prediction model. Through network analysis, we found that multicomponent drugs can present a synergistic effect through regulating inflammatory signaling pathway, invasion pathway, proliferation, and apoptosis pathway. Finally, it was confirmed that the bioactive compounds of compound Liuju formula h...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 17 January 2020Source: Molecular Aspects of MedicineAuthor(s): Rita Lampignano, Vera Kloten, Thomas Krahn, Thomas SchlangeAbstractLiquid biopsy holds great promise to complement traditional analysis on cancerous tissue during clinical management of cancer: screening of patients, (early) disease diagnosis, prognosis, therapy selection as well as early response to treatment and disease monitoring. Among emerging circulating biomarkers, cell-free miRNA (cfmiRNA) may have potential in detecting lung cancer and following the course of the disease. Furthermore, several studies highlighted the p...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Has anyone heard of this? I have a patient who just presented with weight loss and headache- found to have CA lung (most likely, biopsy pending) and a cerebellar lesion. He has always been completely bald but over the past few months, his hair have grown back and now has a full head of hair!! Im guessing its some kind of paraneoplastic phenomenon, but I couldn't find any info?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Dermatology Source Type: forums
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