Nobel Prize in Medicine goes to 3 scientists for discovering how cells use oxygen

Two American and one British scientist won the 2019 Nobel Prize in Physiology or Medicine for discovering how the body's cells sense and react to oxygen levels, work that has paved the way for new strategies to fight anemia, cancer and other diseases, the Nobel committee said.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news

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Conclusion: Data from our study suggest nivolumab is well-tolerated and effective in Indian patients with recurrent advanced NSCLC after failure of the multiple first lines of platinum-based combination chemotherapy.
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Triple-negative breast cancer (TNBC) is associated with worse prognosis, with limited treatment regiments available and higher mortality rate. Immune checkpoint inhibitors targeting programmed cell death-1 (PD-1) or programmed cell death-ligand 1 (PD-L1) showed great potentials in treating malignancies and may serve as potential therapies for TNBC. This systematic review aims to evaluate the efficacy and safety profiles of PD-1/PD-L1 inhibitors in the treatment of TNBC. Literature search was performed via PubMed, EBSCOhost, Scopus, and CENTRAL databases, selecting studies which evaluated the use of anti-PD-1/PD-L1 for TNBC...
Source: Oncology Reviews - Category: Cancer & Oncology Source Type: research
This article examines the recently published guidelines for ESA use in cancer patients from the American Society of Clinical Oncology and American Society of Hematology and attempts to contextualize them to the care of patients with coexistent CKD, cancer, and anemia. PMID: 31596520 [PubMed - as supplied by publisher]
Source: Seminars in Dialysis - Category: Urology & Nephrology Authors: Tags: Semin Dial Source Type: research
Companies are trying to make drugs to alter oxygen sensing in cancer and anemia
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
Companies are trying to make drugs to alter oxygen sensing in cancer and anemia
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
(STOCKHOLM) — A Canadian-American cosmologist and two Swiss scientists won this year’s Nobel Prize in Physics on Tuesday for their work in understanding how the universe has evolved from the Big Bang, and the Earth’s place in it — and for the blockbuster discovery of a first planet outside our solar system. Canadian-born James Peebles, 84, of Princeton University, was credited for “theoretical discoveries in physical cosmology” and Switzerland’s Michel Mayor, 77, and Didier Queloz, 53, each from the University of Geneva, were honored for discovering “an exoplanet orbiting a s...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized Source Type: news
Purpose of review Prolyl-hydroxylase inhibitors are a novel class of orally administered drugs that are under development for the treatment of anemia in patients with chronic kidney disease. This review discusses the biology of these drugs and their target – hypoxia-inducible factor and potential advantages and disadvantages of these therapies. Finally, we will discuss current trials in patients with both chronic kidney disease and end-stage renal disease. Recent findings Recent smaller studies have found that prolyl-hydroxylase are as effective as erythropoietin in treating anemia of chronic kidney disease. We ...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: DIALYSIS AND TRANSPLANTATION: Edited by Anil Chandraker and J. Kevin Tucker Source Type: research
ConclusionsSwitching between ESAs was frequent in both CKD and cancer patients. The number of cumulative transfusions and severity of disease seemed to affect the switch.
Source: BioDrugs - Category: Drugs & Pharmacology Source Type: research
Two Americans and a Briton won the 2019 Nobel Medicine Prize on Monday for discovering a molecular switch that regulates how cells adapt to fluctuating oxygen levels, opening up new approaches to treating heart failure, anaemia and cancer.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Two Americans and an English knight have won this year’s Nobel Prize in Physiology or Medicine for their discovery of how cells detect how much oxygen is available to them and the mechanism that regulates how they adapt to changes in oxygen lev...
Source: Medgadget - Category: Medical Devices Authors: Tags: News Source Type: blogs
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