Stimulus-seeking in rats is accompanied by increased c ‑Fos expression in hippocampal CA1 as well as short 22 kHz and flat 50 kHz calls.

Stimulus-seeking in rats is accompanied by increased c‑Fos expression in hippocampal CA1 as well as short 22 kHz and flat 50 kHz calls.
Acta Neurobiol Exp (Wars). 2019;79(3):309-317
Authors: Robakiewicz I, Polak M, Rawska M, Alberski D, Polowy R, Wytrychiewicz K, Syperek M, Matysiak J, Filipkowski RK
Abstract
We determined CA1 hippocampal field to be involved in self-exposure, a type of novelty‑seeking behaviour that has also been associated with short 22 kHz and flat 50 kHz ultrasonic vocalizations (USV) in adult male Long-Evans rats. Rats were habituated for three days to a self-exposure cage with two nose-poke holes. On day four, the animals from the experimental group were allowed to turn the cage light off for 5 s with a nose‑poke (test/self‑exposure session), while rats from control-yoked group had changing light conditions coupled and identical to the experimental animals. The experimental rats performed more nose-pokes during self-exposure session than animals from the control group. This effect was accompanied by a higher density of c-Fos-positive nuclei in the hippocampal CA1. There were no significant group differences in c-Fos expression in other brain regions analysed. However, possible involvement of several other structures in self-exposure (i.e., CA3, the dentate gyrus, amygdala, prefrontal cortex, and nucleus accumbens) is also discussed, as their correlational activity, reflected by c-Fos immunoactivity, was...

Source: Acta Neurobiologiae Experimentalis - October 8, 2019 Category: Neurology Authors: Robakiewicz I, Polak M, Rawska M, Alberski D, Polowy R, Wytrychiewicz K, Syperek M, Matysiak J, Filipkowski RK Tags: Acta Neurobiol Exp (Wars) Source Type: research