Molecular imaging of extracellular tumor pH to reveal effects of loco-regional therapy on liver cancer microenvironment.

CONCLUSION: MRSI-based pHe-mapping can serve as a longitudinal monitoring instrument for viable tumors. As most liver tumors are hyperglycolytic creating microenvironmental acidosis, therapy-induced normalization of tumor-pHe may be used as a functional biomarker for positive therapeutic outcome.
PMID: 31582517 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - October 2, 2019 Category: Cancer & Oncology Authors: Savic LJ, Schobert I, Peters D, Walsh JJ, Laage Gaupp FM, Hamm CA, Tritz N, Doemel LA, Lin M, Sinusas A, Schlachter T, Duncan JS, Hyder F, Coman D, Chapiro J Tags: Clin Cancer Res Source Type: research