Inflammatory myopathies

Recently, growing evidences suggest that approximately 33-80% of patients with sporadic inclusion body myositis (sIBM) have autoantibodies against cytosolic 5 ′-nucleotidase 1A (cN1A). Although the pathogenic role of anti-cN1A autoantibodies has not been fully investigated, our passive immunization model demonstrated upregulation of p62 level as well as downregulation of cN1A level in the muscle specimen of anti-cN1A-positive sIBM IgG-injected mice. To figure out the pathogenic role of anti-cN1A autoantibodies, we investigated the differences in clinicopathological features between sIBM patients with and without anti-cN1A autoantibodies in this study.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research