O.31Proteomic profiling unravels a key role of CD74, CD163 and STAT1 in sporadic inclusion body myositis

Inclusion body myositis is a chronic muscle-specific disease of adulthood leading to progressive paresis and swallowing difficulties. Muscle biopsy reveals a severe myopathic/dystrophic process with a complex inflammatory infiltrate and presence of protein deposits. Despite the characteristic clinical picture and well-known biopsy findings, the pathogenesis of sIBM is still elusive and not fully understood. In the current study, we applied unbiased proteomic profiling and identified the chaperone and cell surface marker CD74, the macrophage scavenger molecule CD163 and the transcription activator STAT1 to be among the highly and relevantly expressed proteins in muscle biopsies of sIBM patients.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research