Elastography during convex-probe (endobronchial ultrasound) for optimal biopsy sample and gene identification in non-small-cell lung cancer.

Elastography during convex-probe (endobronchial ultrasound) for optimal biopsy sample and gene identification in non-small-cell lung cancer. Biomark Med. 2019 Sep 27;: Authors: Zarogoulidis P, Kosmidis C, Fyntanidou V, Barmpas A, Koulouris C, Aidoni Z, Huang H, Bai C, Hohenforst-Schmidt W, Tsakiridis K, Sapalidis K PMID: 31559839 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research

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Lung cancer has been identified as the leading cause of cancer-related deaths worldwide and one of the most common malignancies in China [1]. More and more non-small cell lung cancer (NSCLC) patients have been observed in the screening projects for detection of early stage lung cancer with the use of low dose computed tomography (CT) [2]. Accurate imaging for evaluation of the Lymph Node Metastases (LNM) could affect the treatment of these patients [3]. Many imaging modalities such as CT, Magnetic Resonance Imaging (MRI), Positron Emission Tomography-CT (PET-CT), as well as other diagnostic techniques like ultrasound-guide...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: MRS/CD45 dual IF staining showed good diagnostic performance and may be a good tool complementing conventional cytology test for determining LN metastasis of NSCLC. PMID: 31637881 [PubMed - in process]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
CONCLUSIONS: ROSE diagnosis has a high concordance with the final diagnosis. PMID: 31618415 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Tags: Am J Clin Pathol Source Type: research
Authors: Zarogoulidis P, Sapalidis K, Fyntanidou V, Kosmidis C, Amaniti A, Koulouris C, Giannakidis D, Tsakiridis K, Aidoni Z, Romanidis K, Oikonomou A, Huang H, Freitag L, Hohenforst-Schmidt W Abstract Introduction: Non-small cell lung cancer is still diagnosed at a late stage although we have new diagnostic equipment such the radial endobronchial ultraound, convex probe endobronchial ultrasound and electromagnetic navigation. The dianostic techniques have been upgraded with rapid on site evaluation (ROSE) and currently from 2014 real time elastography is being evaluated as a ROSE technique. Areas covered: A thoro...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
ConclusionsUS is a promising physical method to enhance anticancer drug efficacy, especially into 3D cell cultures. However, there is a lack of evidence about its efficacy and further studies are needed.Legal entity responsible for the studyThe authors.FundingLithuanian University of Health Sciences; Kaunas University of Technology.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Abstract RATIONALE: When stereotactic ablative radiotherapy (SABR) is an option for non-small cell lung cancer (NSCLC) patients, distinguishing between N0, N1 and N2 or N3 (N2|3) disease is important. OBJECTIVES: To develop a prediction model for estimating the probability of N0, N1, and N2|3 disease. METHODS: Consecutive patients with clinical-radiographic stage T1-3/N0-3/M0 NSCLC that underwent endobronchial ultrasound-guided staging from a single center were included. Multivariate ordinal logistic regression analysis was used to predict the presence of N0, N1 or N2|3 disease. Temporal validation used ...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Conclusions: Occult LN MMs can be detected in EBUS-TBNA specimens obtained during staging examinations and are associated with poor clinical outcomes. If prospectively confirmed, these results have significant implications for EBUS-TBNA specimen analyses and possibly for the NSCLC staging paradigm. PMID: 31559073 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
It is universally accepted that endosonography, either endobronchial ultrasound with transbronchial needle aspiration (EBUS-TBNA) or endoscopic ultrasound with fine-needle aspiration biopsy (EUS-FNA), has become the gold standard technique, replacing surgical mediastinal staging (mediastinoscopy, mediastinotomy, video-assisted thoracoscopic surgery, video-assisted mediastinoscopic lymphadenectomy, transcervical extended mediastinal lymphadenectomy) as the first test of choice for staging the mediastinum in patients with non –small cell lung cancer (NSCLC).
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Commentary Source Type: research
Publication date: September 2019Source: Journal of Vascular and Interventional Radiology, Volume 30, Issue 9Author(s): Lili Zheng, Fubo Zhou, Xiaoling Yu, Ping Liang, Zhigang Cheng, Zhiyu Han, Jie Yu, Fangyi Liu, Weiping WangAbstractPurposeTo identify risk factors for hypertensive crisis (HC) during ultrasound-guided percutaneous microwave (MW) ablation of adrenal neoplasms.Materials and MethodsPatients who underwent MW ablation for adrenal tumors between April 2006 and November 2017 were retrospectively identified for this study (51 consecutive patients; 35 males, 16 females; mean age, 55 years; range, 15–85 years)....
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
We describe two patients with advanced non ‐small‐cell lung cancer (NSCLC), including one in whom the definitive diagnosis of pulmonary pleomorphic carcinoma (PPC) was made by histopathology of the resected tumour and another in whom the diagnosis of “favor adenocarcinoma containing sarcomatoid components” was made by tissue biopsy. Both were resistant to first line platinum‐based chemotherapy, but responded dramatically to second line nivolumab therapy. We present two cases of pulmonary pleomorphic carcinoma (PPC) treated with Nivolumab. A 57 ‐year‐old man presented with a 3.5‐cm mass in the left l...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
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