Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and 18F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma.

Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and 18F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma. Magn Reson Med Sci. 2019 Sep 24;: Authors: Imaizumi A, Obata T, Kershaw J, Tachibana Y, Inubushi M, Koizumi M, Yoshikawa K, Zhang MR, Tanimoto K, Harada R, Uno T, Saga T Abstract We investigated the usefulness of diffusion-weighted imaging (DWI) for detecting changes in the structure of hypoxic cells by evaluating the correlation between 18F-fluoroazomycin arabinoside (FAZA) positron emission tomography activity and DWI parameters in head and neck carcinoma. The diffusion coefficient corresponding to the slow compartment of a two-compartment model had a significant positive correlation with FAZA activity (ρ = 0.58, P = 0.016), whereas the diffusional kurtosis from diffusion kurtosis imaging had a significant negative correlation (ρ = -0.62, P = 0.008), which suggests that those DWI parameters might be useful as indicators for changes in cell structure. PMID: 31548478 [PubMed - as supplied by publisher]
Source: Magnetic Resonance in Medical Sciences - Category: Radiology Tags: Magn Reson Med Sci Source Type: research