CUDC ‑907 reverses pathological phenotype of keloid fibroblasts in vitro and in vivo via dual inhibition of PI3K/Akt/mTOR signaling and HDAC2.

CUDC‑907 reverses pathological phenotype of keloid fibroblasts in vitro and in vivo via dual inhibition of PI3K/Akt/mTOR signaling and HDAC2. Int J Mol Med. 2019 Sep 23;: Authors: Tu T, Huang J, Lin M, Gao Z, Wu X, Zhang W, Zhou G, Wang W, Liu W Abstract Keloids are benign skin tumors with a high recurrence rate following surgical excision. Abnormal intracellular signaling is one of the key mechanisms involved in its pathogenesis. Over‑activated phosphoinositide 3‑kinase/RAC‑alpha serine/threonine‑protein kinase/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway and overproduction of histone deacetylases 2 (HDAC2) have also been observed in keloid fibroblasts (KFs). The present study aimed to explore the possibility of reversing the KF pathological phenotype using CUDC‑907, a dual inhibitor of PI3K/Akt/mTOR pathway and HDACs. KFs and keloid xenografts were treated with CUDC‑907 to examine its inhibitory effects on the pathological activities of KFs in vitro and in vivo. CUDC‑907 inhibited cell proliferation, migration, invasion and extracellular matrix deposition of in vitro cultured KFs and also suppressed collagen accumulation and disrupted the capillaries of keloid explants ex vivo and in vivo. A mechanistic study of CUDC‑907 revealed the initiation of cell cycle arrest at G2/M phase along with the enhanced expression of cyclin‑dependent kinase inhibitor 1 and decreased expression of cyclin B in cells treated with CUDC...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research

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Publication date: Available online 16 January 2020Source: BurnsAuthor(s): Ernest A. Azzopardi, Robert T. Duncan, Mollie Kearns, Francesco Marangoni, Nader Ibrahim, Ernest A.F. Azzopardi, Dean Boyce, Matteo Tretti, Maxwell S.C. MursionAbstractThermal disease presents a major burden to individual patient morbidity, healthcare cost as well as to over all economy. Burns also also represent a significant per-patient utlilisation of finite healthcare resources. Secondary complications in these patients, such as multiple drug resistant organisms, may have a devastating effect.Laser surgery has recently come of age as an optimal t...
Source: Burns - Category: Dermatology Source Type: research
Injury to skin triggers natural wound healing responses that may lead to scar formation, or excessive deposition of the extracellular matrix, mostly containing collagen [1]. With technological advances, many minimally or non-invasive means of treating scars have been used and are fairly effective, although results may be modest in keloids or hypertrophic scars [2]. Topical or injectable agents (i.e. steroids, interferon, 5-fluorouracil, plasma), passive microneedling, radiofrequency (RF) microneedling, fractional and non-ablative laser technology, radiation, high intensity focused ultrasound (HIFU), and cryotherapy have al...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
Publication date: Available online 15 January 2020Source: Life SciencesAuthor(s): Jing Cui, Shan Jin, Chenglong Jin, Zhehu JinAbstractAimsThe present study aimed to explore the effect of syndecan-1 on keloid fibroblasts.Main methodsImmunohistochemistry and Western blot were employed to assess the expression of syndecan-1. Primary cultured keloid fibroblasts were transfected with syndecan-1 siRNA. The function of syndecan-1 on the proliferation of keloid fibroblasts was investigated through Cell Counting Kit-8 (CCK-8) and flow cytometry. Extracellular matrix, TGF-β1/Smad, and MAPK related proteins were evaluated by Wes...
Source: Life Sciences - Category: Biology Source Type: research
In this study, we evaluated 363 patients with metastases to lymph nodes and 45 patients with synchronous liver metastases who underwent curative resection. DRLN and DRliver statuses were classified as mature, intermediate, or immature, based on keloid-like collagen and myxoid stroma appearances in the metastatic lesions. Overall, 109, 106, and 148 patients had mature, intermediate, and immature DRLN, respectively; in total, 5, 21, and 19 patients had mature, intermediate, and immature DRliver, respectively. DRLN and DRprimary (spearman ’s rho = 0.43,P 
Source: Virchows Archiv - Category: Pathology Source Type: research
Authors: Sun P, Hu Z, Pan B, Lu X Abstract Keloid is a common and frequently-occurring disease in plastic surgery, and its ugly appearance and itching symptoms bring mental and life pain to patients. However, the clinical treatment of keloid, such as drug injection treatment, surgical resection, cryotherapy, laser treatment and other therapeutic effects are poor. Since the discovery of tumor necrosis factor related apoptosis inducing ligand (TRAIL) in 1995, its selective apoptosis on tumor cells makes it have a great prospect in the targeted treatment of tumor. In recent years, it has been found that the formation ...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
In conclusion, our data could provide an explanation regarding the inconsistent efficacy of topic therapies for hypertrophic scars. PMID: 31912089 [PubMed - in process]
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Photochem. Photobiol. Sci., 2020, Accepted Manuscript DOI: 10.1039/C9PP00311H, PaperXiaomei Cui, Jing Zhu, Xiaoyan Wu, Shengju Yang, Xiaodong Yao, Wenyan Zhu, Pan Xu, Xiaodong Chen Photodynamic therapy (PDT) has been shown to significantly inhibit fibroblast activity. However, the effect of PDT mediated by the photosensitizer hematoporphyrin monomethyl ether (HMME) on keloids is not known well.... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Photochem. Photobiol. Sci. latest articles - Category: Chemistry Authors: Source Type: research
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Source: Cell Cycle - Category: Cytology Authors: Source Type: research
Mycosis fungoides (MF) is the most common type of cutaneous T ‐cell lymphoma (CTCL). It may arise rapidly in a scar or keloid, presumably due to a long‐standing proliferative state or autoimmune theory. There should be a low threshold for performing a skin biopsy if unusual lesions develop at those sites. AbstractMycosis fungoides (MF) is the most common type of cutaneous T ‐cell lymphoma (CTCL). It may arise rapidly in a scar or keloid, presumably due to a long‐standing proliferative state or autoimmune theory. There should be a low threshold for performing a skin biopsy if unusual lesions develop at those sites.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
Conditions:   Acne;   Acne Vulgaris;   Acne Keloidalis;   Acne Keloid;   Acne Conglobata;   Acne Rosacea;   Acne Inversa;   Acne Cystic;   Acne Pomade;   Acne Indurata;   Acne Papular;   Acne Tropica;   Acne Urticata;   Acne Fulminans;   Acne Follicular;   Acne Tropicalis;   Acn e Detergicans;   Acne Iodide;   Acne Varioliformis Intervention:   Other: No intervention Sponsor:   ProgenaBiome Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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