Uremic Toxins, Oxidative Stress, and Renal Fibrosis: An Interwined Complex

The prevalence of end-stage renal diseases is currently on the rise globally, and finding the way to curb this tide is urgently needed. Tubulointerstitial fibrosis is a common pathway for essentially all the nephropathy categories known to date, and the manifestations of renal fibrosis include excessive deposition of extracellular matrix with distortion of renal microstructures and functional deterioration. Uremic toxins have been gradually found to play an important role in the development of progressive renal fibrosis, with protein-bound indoxyl sulfate, p-cresol, and p-cresyl sulfate receiving the most attention.
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: Icurt Proceedings Source Type: research