Molecules, Vol. 24, Pages 3407: Targeted Delivery of Plasminogen Activators for Thrombolytic Therapy: An Integrative Evaluation
Molecules, Vol. 24, Pages 3407: Targeted Delivery of Plasminogen Activators for Thrombolytic Therapy: An Integrative Evaluation
Molecules doi: 10.3390/molecules24183407
Authors:
Yunn-Hwa Ma
Chih-Hsin Liu
Yueh Liang
Jyh-Ping Chen
Tony Wu
In thrombolytic therapy, plasminogen activators (PAs) are still the only group of drug approved to induce thrombolysis, and therefore, critical for treatment of arterial thromboembolism, such as stroke, in the acute phase. Functionalized nanocomposites have attracted great attention in achieving target thrombolysis due to favorable characteristics associated with the size, surface properties and targeting effects. Many PA-conjugated nanocomposites have been prepared and characterized, and some of them has been demonstrated with therapeutic efficacy in animal models. To facilitate future translation, this paper reviews recent progress of this area, especially focus on how to achieve reproducible thrombolysis efficacy in vivo.
Source: Molecules - Category: Chemistry Authors: Yunn-Hwa Ma Chih-Hsin Liu Yueh Liang Jyh-Ping Chen Tony Wu Tags: Review Source Type: research