Laryngeal sarcoidosis in a child: Case report

Publication date: Available online 19 September 2019Source: Reumatología Clínica (English Edition)Author(s): Gabriel Vega-Cornejo, Priscila Ayala-BuenrostroAbstractSarcoidosis is a chronic, multisystemic, granulomatous disorder. Our patient was a 2-year-old girl with multiple airway conditions and a partial response to inhaled and systemic steroids. She was positive for acute phase reactants and negative for antibodies. Polymerase chain reaction revealed atypical Mycobacteria and she was negative for Mycobacterium tuberculosis. Laryngeal sarcoidosis was diagnosed by histopathology in a biopsy of larynx that revealed a chronic granulomatous inflammatory process with Langhans giant cells and acute and ulcerated areas with changes compatible with tuberculosis. Treatment consisted of monthly gammaglobulin for 6 months at doses of 2 g/kg body weight, accompanied by Valmetrol™ and methotrexate. Immunomodulation with gammaglobulin was prescribed, with subsequent use of methotrexate-based immunosuppression. Currently, bronchoscopy shows no evidence of granulomas and she is negative for acute-phase reactants.ResumenLa sarcoidosis es un trastorno crónico, multisistémico y granulomatoso. Femenina de 2 años con múltiples cuadros de vías respiratorias, con esteroides inhalados y sistémicos presentando respuesta parcial, reactantes de fase aguda positivos, anticuerpos negativos, además de PCR de micobacterias at&iacu...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research

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​Seventy-five percent of trauma injuries involve some kind of thoracic insult, a quarter of which need a procedural intervention like a chest tube. (Surg Clin North Am 2007;87[1]:95; Long-term illness, lung disease, and post-operative complications may cause pleural effusions or a pneumothorax, so treating these conditions quickly can significantly decrease patient morbidity and mortality. Other indications for chest tube placement include:Trauma: Pneumothorax, hemopneumothorax, or tension pneumothoraxLong-term illness: Pleural effusion (cancer, pneumonia)Infection: Empyema, purulent pleuriti...
Source: The Procedural Pause - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
In this article, we present a unique case of active pulmonary tuberculosis, with multiple huge “cluster” signs like fireworks, together with multiple “galaxy” signs. The repeated acid‐fast sputum smears and both bronchial washings were all negative forMycobacterium tuberculosis, but the acid ‐fast culture of sputum taken soon after the first bronchoscopy, and pleural fluid, turned out to be positive forM. tuberculosis at six weeks after admission. The present case clearly demonstrates that the “galaxy” and “cluster” signs are red herring signs of the low rates of isolatin...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Conclusion: The most sensitivity pCLE has in patients with MLD. Further researches is necessary
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional Pulmonology Source Type: research
Conclusions: A consistent proportion of endobronchial benign lesions are reported. One fifth of these are associated with critical stenosis of the airway lumen, requiring rigid bronchoscopy. Among these, aspergillosis is characterized by the poorest prognosis, regardless of host immunity status.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
Conclusion Only a few diagnostic tests are useful for the etiological assessment of uveitis. They are often cheap, simple, more often guided by the clinical findings, and lead to an etiological diagnosis in most patients. On the other hand, some tests are never or exceptionally contributive, such as immunological tests or intracellular serologies. Further studies are required to evaluate the profitability of third intention imagery and invasive investigations.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Conclusion: Endobronchial tuberculosis was the most frequent reason for paediatric RB beyond foreign body removal. Although being invasive, RB allowed a secure airway and therapeutic intervention, with no major complications.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric Bronchology Source Type: research
Authors: Darwiche K, Özkan F, Wolters C, Eisenmann S Abstract Endobronchial Ultrasound (EBUS) with the two modalities curved and radial EBUS significantly improved the diagnostics in several pulmonary diseases. The examination and staging of mediastinal and hilar lymph nodes in patients with known or suspected lung malignancy as well as the evaluation of unknown pulmonary or mediastinal lesions can be achieved with minimal invasive means when using EBUS. More invasive surgical procedures for diagnostic purposes can be omitted. The diagnostic yield also increases when EBUS is applied in sarcoidosis or mediast...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
T Aktas, F Aktas, Z Ozmen, N Yaşayancan, A ArıcıNigerian Journal of Clinical Practice 2017 20(4):495-497Tracheobroncopathia osteochondroplastica (TO) is a benign disease of the large airways seen very rarely. It is characterized by 1-3 mm sized ossified nodular lesions in submucosa. Its etiology is unclear, but it is stated that malignancy, chronic inflammation, amyloidosis, and genetic factors might have an effect on it. It was first described by Wilks in a 38-year-old man diagnosed with tuberculosis in 1857. Generally, patients are asymptomatic and TO is diagnosed incidentally. But symptoms become signific...
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
Conclusion Identification of factors associated with abnormal investigations might improve the optimal diagnostic workup adapted to each patient.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Publication date: Available online 5 March 2016 Source:Respiratory Investigation Author(s): Takahiro Nakajima , Kazuhiro Yasufuku , Taiki Fujiwara , Ichiro Yoshino Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive modality for sampling of mediastinal and hilar lymph nodes as well as pulmonary lesions adjacent to the airway. Guidelines for staging of lung cancer suggest that EBUS-TBNA should be considered the best first test of nodal staging for radiologically abnormal lymph nodes that are accessible by this approach. The application of EBUS-TBNA in pulmonary medicine...
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
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