Simple preparation of 58S bioactive glass/polycaprolactone composite scaffolds by freeze-drying under ambient conditions

Publication date: 1 December 2019Source: Materials Letters, Volume 256Author(s): Diogo Santos, Talita Martins, Sandhra Carvalho, Marivalda Pereira, Manuel Houmard, Eduardo NunesAbstractComposite scaffolds were successfully obtained using sol-gel derived 58S bioactive glass particles and poly(ε-caprolactone) pellets. Camphene was used as the freezing vehicle. No sintering step was used, which represents a great advantage in terms of energy and time-saving. The prepared scaffolds showed a mechanical behavior similar to elastomeric cellular solids and Young’s modulus of 46.7 ± 9.4 MPa, which may allow their use in load-bearing applications. Cytotoxicity tests revealed that the composites promoted the growth of human osteosarcoma cells. The formation of a hydroxyapatite layer on the surface of the samples was also observed after soaking them in a simulated body fluid solution.Graphical abstract
Source: Materials Letters - Category: Materials Science Source Type: research