Hijacking of GABAA Receptors by Mutant Glycine Receptors.
Hijacking of GABAA Receptors by Mutant Glycine Receptors.
Trends Mol Med. 2019 Sep 11;:
Authors: Harvey RJ
Abstract
Startle disease results from mutations in genes encoding inhibitory GlyR α1 and β subunits or the presynaptic glycine transporter GlyT2. However, the most effective therapies are benzodiazepines that potentiate inhibitory GABAAR function. A recent publication by Zou et al. adds further complexity by suggesting that dominant GlyR α1 mutants assemble into pre- and extrasynaptic GABAARs.
PMID: 31521561 [PubMed - as supplied by publisher]
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Harvey RJ Tags: Trends Mol Med Source Type: research