A primitive plasma cell leukemia with immunoglobulin (Ig) E.

We report here a case of primitive plasma cell leukemia with immunoglobulin (Ig) E. IgE myeloma is an exceptional variant of multiple myeloma, with a very poor prognosis. Its biological diagnosis requires specific analyzes in order to detect IgE gammopathy. Plasma cell leukemia (PCL) is also a very rare and very severe form of multiple myeloma. There are two variants: primitive PCL (pPCL) occurring de novo and secondary PCL (sPCL), evolution of a preexisting myeloma. Its diagnosis is essentially biological since it is defined by a blood plasmocytosis greater than 2 G/L or 20% of the leucocytes.
PMID: 31512579 [PubMed - as supplied by publisher]

Source: Annales de Biologie Clinique - September 10, 2019 Category: Biochemistry Authors: Rachidi M, Lazarian G, Letestu R, Lusina D, Desbene C, Vidal V, Eclache V, Baran-Marszak F, Cymbalista F, Fleury C Tags: Ann Biol Clin (Paris) Source Type: research